Results 41 to 50 of about 11,418,435 (287)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

CRISPR-Clear: A Fieldable Detection Procedure for Potential CRISPR-Cas9 Gene Drive Based Bioweapons [PDF]

, 2019
Rapid progression in genetic modification research has made gene editing increasingly cheaper and easier to use. CRISPR-Cas9 for example, allows for the specific alteration of the genome of an organism with relative simplicity and low costs.
Vittorio, Saggiomo, Angelina, Horsting, Aldrik, Velders, Jorrit W., Hegge, Martijn M., van Galen, Anna C., Nieuwenweg   +5 more
core   +2 more sources

Gene drives for schistosomiasis transmission control.

PLoS Neglected Tropical Diseases, 2019
Schistosomiasis is one of the most important and widespread neglected tropical diseases (NTD), with over 200 million people infected in more than 70 countries; the disease has nearly 800 million people at risk in endemic areas.
Theresa Maier, Nicolas James Wheeler, Erica K O Namigai, Josh Tycko, Richard Ernest Grewelle, Yimtubezinash Woldeamanuel, Katharina Klohe, Javier Perez-Saez, Susanne H Sokolow, Giulio A De Leo, Timothy P Yoshino, Mostafa Zamanian, Jutta Reinhard-Rupp   +12 more
doaj   +1 more source

Modeling the efficacy of CRISPR gene drive for snail immunity on schistosomiasis control.

PLoS Neglected Tropical Diseases, 2022
CRISPR gene drives could revolutionize the control of infectious diseases by accelerating the spread of engineered traits that limit parasite transmission in wild populations.
Richard E Grewelle, Javier Perez-Saez, Josh Tycko, Erica K O Namigai, Chloe G Rickards, Giulio A De Leo   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The suppressive potential of a gene drive in populations of invasive social wasps is currently limited

Scientific Reports, 2023
Social insects are very successful invasive species, and the continued increase of global trade and transportation has exacerbated this problem. The yellow-legged hornet, Vespa velutina nigrithorax (henceforth Asian hornet), is drastically expanding its ...
Adriaan B. Meiborg, Nicky R. Faber, Benjamin A. Taylor, Brock A. Harpur, Gregor Gorjanc   +4 more
doaj   +1 more source

Gene Drive and Symbiont Technologies for Control of Mosquito-Borne Diseases

Annual Review of Entomology
Mosquito-borne diseases, such as dengue and malaria, pose a significant burden to global health. Current control strategies with insecticides are only moderately effective. Scalable solutions are needed to reduce the transmission risk of these diseases.
Guan-Hong, Wang, Ary, Hoffmann, Jackson, Champer   +2 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

ETHICS OF GENE DRIVE MOSQUITOES FOR MALARIA ELIMINATION [PDF]

, 2022
This thesis is concerned with presenting analyses regarding key ethical issues regarding and arising from the development and potential use of gene drive modified mosquitoes for the purpose of malaria elimination.
Roberts, Aaron J.
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source