Results 21 to 30 of about 11,418,435 (287)

Designing gene drives to limit spillover to non-target populations.

PLoS Genetics, 2021
The prospect of utilizing CRISPR-based gene-drive technology for controlling populations has generated much excitement. However, the potential for spillovers of gene-drive alleles from the target population to non-target populations has raised concerns ...
Gili Greenbaum, Marcus W Feldman, Noah A Rosenberg, Jaehee Kim   +3 more
doaj   +1 more source

Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes

Nature Communications, 2020
Genetic variation in natural populations could represent gene drive resistant alleles, preventing successful application for population management. Here the authors survey 1280 genomes from three mosquito species and concludes natural variation will not ...
Hanno Schmidt, Travis C. Collier, Mark J. Hanemaaijer, Parker D. Houston, Yoosook Lee, Gregory C. Lanzaro   +5 more
doaj   +1 more source

Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey

Malaria Journal, 2021
Background Innovative tools are needed to complement the existing approach for malaria elimination. Gene drive mosquitoes are one potential new technology in the control of malaria vectors.
Lea Pare Toe, Nourou Barry, Anselme D. Ky, Souleymane Kekele, Wilfrid Meda, Korotimi Bayala, Mouhamed Drabo, Delphine Thizy, Abdoulaye Diabate   +8 more
doaj   +1 more source

Ugandan stakeholder hopes and concerns about gene drive mosquitoes for malaria control: new directions for gene drive risk governance

Malaria Journal, 2021
Background The African Union’s High-Level Panel on Emerging Technologies identified gene drive mosquitoes as a priority technology for malaria elimination. The first field trials are expected in 5–10 years in Uganda, Mali or Burkina Faso. In preparation,
Sarah Hartley, Robert D. J. Smith, Adam Kokotovich, Chris Opesen, Tibebu Habtewold, Katie Ledingham, Ben Raymond, Charles B. Rwabukwali   +7 more
doaj   +1 more source

The Analytical Review on Futuristic use of CRISPR-Cpf1 Aided Gene Drive Technology [PDF]

International Journal of Trend in Scientific Research and Development, 2018
Organisms edited by gene editing or traditional selective breeding are typically less able to survive and reproduce which effectively prevents those alterations from spreading in the wild populations. This paper focuses on how the CRISPR Cpf1 system can be used to build a Gene Drive capable of spreading particular alterations in the wild population ...
Rohit Satyam, Nishtha Singh, Tulika Bhardwaj   +2 more
openaire   +2 more sources

First Steps towards Underdominant Genetic Transformation of Insect Populations [PDF]

, 2014
The idea of introducing genetic modifications into wild populations of insects to stop them from spreading diseases is more than 40 years old. Synthetic disease refractory genes have been successfully generated for mosquito vectors of dengue fever and ...
Reeves R. Guy, Philipp M. Altrock (340203), Jarosław Bryk, R Guy Reeves, Altrock, P., Jai A. Denton (185794), Jarosław Bryk (47108), Jai A Denton, Bryk, J., R. Guy Reeves (185792), Philipp M Altrock, Bryk, Jarek, Denton Jai A., Reed, F., Denton, Jai A., Floyd A Reed, Floyd A. Reed (185797), Altrock Philipp M., Reed, Floyd A., Altrock, Philipp M., Reeves, R. Guy, Bryk Jarosław, Reed Floyd A., Reeves, R., Denton, J.   +24 more
core   +2 more sources

Gene drives in our future: challenges of and opportunities for using a self-sustaining technology in pest and vector management

BMC Proceedings, 2018
Gene drives are systems of biased inheritance that enhance the likelihood a sequence of DNA passes between generations through sexual reproduction and potentially throughout a local population and ultimately all connected populations of a species.
James P. Collins
doaj   +1 more source

Assessment of distant-site rescue elements for CRISPR toxin-antidote gene drives

Frontiers in Bioengineering and Biotechnology, 2023
Gene drive is a genetic engineering technology that can enable super-mendelian inheritance of specific alleles, allowing them to spread through a population.
Jingheng Chen, Xuejiao Xu, Jackson Champer   +2 more
doaj   +1 more source

Using Gene Drive Technologies to Control Vector-Borne Infectious Diseases [PDF]

Sustainability, 2018
After years of success in reducing the global malaria burden, the World Health Organization (WHO) recently reported that progress has stalled. Over 90% of malaria deaths world-wide occurred in the WHO African Region. New tools are needed to regain momentum and further decrease the burden of malaria.
James, Stephanie, Tountas, Karen H.
openaire   +1 more source

Developing gene drive technologies to eradicate invasive rodents from islands [PDF]

Journal of Responsible Innovation, 2017
Island ecosystems are highly threatened by invasive rats and mice. Currently, the only effective technology for eradicating rodents from islands is toxicants.
Caroline M. Leitschuh, Dona Kanavy, Gregory A. Backus, Rene X. Valdez, Megan Serr, Elizabeth A. Pitts, David Threadgill, John Godwin   +7 more
openaire   +1 more source