Results 251 to 260 of about 519,971 (295)

The haplolethal gene wupA of Drosophila exhibits potential as a target for an X-poisoning gene drive. [PDF]

G3 (Bethesda)
Lawler CD, Nuñez AKP, Hernandes N, Bhide S, Lohrey I, Baxter S, Robin C.   +6 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Gene drive and genetic sex conversion in the global agricultural pest Ceratitis capitata. [PDF]

Nat Commun
Meccariello A, Hou S, Davydova S, Fawcett JD, Siddall A, Leftwich PT, Krsticevic F, Papathanos PA, Windbichler N.   +8 more
europepmc   +1 more source

A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations. [PDF]

Nat Commun
Anderson MAE, Gonzalez E, Edgington MP, Ang JXD, Purusothaman DK, Shackleford L, Nevard K, Verkuijl SAN, Harvey-Samuel T, Leftwich PT, Esvelt K, Alphey L.   +11 more
europepmc   +1 more source

Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cages. [PDF]

Nat Commun
D'Amato R, Taxiarchi C, Galardini M, Trusso A, Minuz RL, Grilli S, Somerville AGT, Shittu D, Khalil AS, Galizi R, Crisanti A, Simoni A, Müller R.   +12 more
europepmc   +1 more source

Chemical Controllable Gene Drive in Drosophila

ACS Synthetic Biology, 2020
Gene drive systems that propagate transgenes via super-Mendelian inheritance can potentially control insect-borne diseases and agricultural pests. However, concerns have been raised regarding unforeseen ecological consequences, and methods that prevent ...
Dongwoo Chae, Junwon Lee, Kyungsoo Park   +2 more
exaly   +3 more sources

Embracing Dynamic Models for Gene Drive Management

Trends in Biotechnology, 2021
Robust methods of predicting how gene drive systems will interact with ecosystems is essential for safe deployment of gene drive technology. We describe how quantitative tools can reduce risk uncertainty, streamline empirical research, guide risk ...
Andrew J Golnar, Emily Ruell, Alun L Lloyd   +2 more
exaly   +2 more sources

Prescribing engagement in environmental risk assessment for gene drive technology

Regulation and Governance, 2023
Gene drive technology is a nascent biotechnology with the potential to purposefully alter or eliminate a species. There have been broad calls for engagement to inform gene drive governance.
Sarah Hartley, Adam Kokotovich
exaly   +2 more sources

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Evolution-driving genes

Research in Microbiology, 2000
Genomic sequences provide evidence for a common origin of life and its evolution via selection of genetic variants created by mutation and recombination. Two classes of genes are known to accelerate mutation and/or recombination rates in bacterial populations: stress-inducible wild-type genes, usually part of the SOS regulon, and genes whose functional
M, Radman, F, Taddei, I, Matic
openaire   +2 more sources

Genes Driving the Colonoscope

Gastrointestinal Endoscopy Clinics of North America, 1997
Recent molecular genetic studies have significantly advanced our understanding of colorectal tumorigenesis. Important genetic alterations have been characterized with practical as well as biologic implications. Presymptomatic genetic testing is now available for two major inherited colorectal cancer predisposition syndromes.
openaire   +2 more sources