Results 261 to 270 of about 1,021,897 (307)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cages. [PDF]

Nat Commun
D'Amato R, Taxiarchi C, Galardini M, Trusso A, Minuz RL, Grilli S, Somerville AGT, Shittu D, Khalil AS, Galizi R, Crisanti A, Simoni A, Müller R.   +12 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii. [PDF]

PLoS Genet
Ma S, Ni X, Chen S, Qiao X, Xu X, Chen W, Champer J, Huang J.   +7 more
europepmc   +1 more source

Genetic and geographic population structure in the malaria vector, Anopheles farauti, provides a candidate system for pioneering confinable gene-drive releases. [PDF]

Heredity (Edinb)
Ambrose L, Allen SL, Iro'ofa C, Butafa C, Beebe NW.   +4 more
europepmc   +1 more source

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Evolution-driving genes

Research in Microbiology, 2000
Genomic sequences provide evidence for a common origin of life and its evolution via selection of genetic variants created by mutation and recombination. Two classes of genes are known to accelerate mutation and/or recombination rates in bacterial populations: stress-inducible wild-type genes, usually part of the SOS regulon, and genes whose functional
M, Radman, F, Taddei, I, Matic
openaire   +2 more sources

Genes Driving the Colonoscope

Gastrointestinal Endoscopy Clinics of North America, 1997
Recent molecular genetic studies have significantly advanced our understanding of colorectal tumorigenesis. Important genetic alterations have been characterized with practical as well as biologic implications. Presymptomatic genetic testing is now available for two major inherited colorectal cancer predisposition syndromes.
openaire   +2 more sources

Genes drive organisms and slippery slopes

Pathogens and Global Health, 2022
The bioethical debate about using gene drives to alter or eradicate wild populations has focused mostly on issues concerning short-term risk assessment and management, governance and oversight, and public and community engagement, but has not examined big-picture- 'where is this going?'-questions in great depth. In other areas of bioethical controversy,
David B, Resnik, Raul F, Medina, Fred, Gould, George, Church, Jennifer, Kuzma   +4 more
openaire   +2 more sources

Incorporating ecology into gene drive modelling

Ecology Letters, 2023
AbstractGene drive technology, in which fast‐spreading engineered drive alleles are introduced into wild populations, represents a promising new tool in the fight against vector‐borne diseases, agricultural pests and invasive species. Due to the risks involved, gene drives have so far only been tested in laboratory settings while their population‐level
Jaehee Kim, Keith D. Harris, Isabel K. Kim, Shahar Shemesh, Philipp W. Messer, Gili Greenbaum   +5 more
openaire   +2 more sources

Precaution: Open gene drive research

Science, 2017
In their Policy Forum “Precaution and governance of emerging technologies” (11 November 2016, p. [710][1]), G. E. Kaebnick and colleagues convincingly assert that precaution is consistent with support for science.
openaire   +2 more sources