Results 141 to 150 of about 11,418,435 (287)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
, 2002 Ch. 1. Gene technology and economy / Susanne Lundin & Lynn Åkesson -- Ch. 2. Genetic engineering and economics: a challenge to north-south inequalities / Göte Hansson -- Ch. 3. Medical databases: the Icelandic case / Gísli Pádlsson -- Ch. 4.
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Controversial issues in biology: Using gene-drive technology to eliminate mosquito borne disease
This white paper was developed for BIOL 700, a seminar-style course at the University of New Hampshire that explores the intersection of biological science, ethics, and public policy. The report provides a comprehensive analysis of the clinical and ethical debate surrounding the question: "Are neurons the only cells in the brain driving behavior?"
Marconi, Joe +2 more
openaire +2 more sources
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Gene Allen Oral History (part 1)
Gene Allen, Art Director of "My Fair Lady", "A Star is Born", and "Les Girls".
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Magnetic nanoparticles for gene and drug delivery
International Journal of Nanomedicine, 2008 Stuart C McBain, Humphrey HP Yiu, Jon DobsonInstitute of Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, Staffordshire, ST4 7QB, U.K.Abstract: Investigations of magnetic micro- and nanoparticles for ...
Stuart C McBain +2 more
doaj
ESA Position Statement on the Importance of Continued Innovation in Gene Drive Technology [PDF]
Annals of the Entomological Society of America, 2020 openaire +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source