Results 151 to 160 of about 189,147 (282)

Response to "Field Trials Need Genetic Localization, Not Geographic Isolation". [PDF]

Am J Trop Med Hyg
Lanzaro GC, Kormos AM.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Controversial issues in biology: Using gene-drive technology to eliminate mosquito borne disease

Joe Marconi, Laurel Pigman, Hannah Pettigrew   +2 more
openalex   +2 more sources

Emerging trends in genome editing of wild animals. [PDF]

Transgenic Res
Blix T, Myhr AI.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Is Gene Drive Research Losing Traction? [PDF]

Am J Trop Med Hyg
Lanzaro GC, Kormos AM.
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Gene-drive-capable mosquitoes suppress patient-derived malaria in Tanzania. [PDF]

Nature
Habtewold T, Lwetoijera DW, Hoermann A, Mashauri R, Matwewe F, Mwanga R, Kweyamba P, Maganga G, Magani BP, Mtama R, Mahonje MA, Tambwe MM, Tarimo F, Chennuri PR, Cai JA, Del Corsano G, Capriotti P, Sasse P, Moore J, Hudson D, Manjurano A, Tarimo B, Vlachou D, Moore S, Windbichler N, Christophides GK.   +25 more
europepmc   +1 more source

Exploring experts’ uncertainties about gene drive technology for agricultural pest control in the U.S.: a qualitative study to inform innovation and decision-making [PDF]

Nourou Barry, S Barnhill, Branden B. Johnson   +2 more
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source