Results 211 to 220 of about 11,418,435 (287)

Optimization of AAV tools to target Müller glial cells for retinal gene therapy. [PDF]

Mol Ther Adv
Urrutia-Cabrera D, Huppert G, Chu SWL, Wang L, Nguy CB, Liu CF, Lisowski L, Luu CD, Wang JH, Hung S, Hewitt AW, Huang CL, Edwards T, Martin KR, Wong RCB.   +14 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Evolving conservation: The role of unconventional approaches to restore contemporary vertebrate populations and genomic biodiversity. [PDF]

J Hered
vonHoldt BM, James M, Gaughran SJ, DeCandia AL, Koepfli KP, Flores D, Songsasen N, Brzeski KE, Jensen EL.   +8 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

UTMD Suppresses CSF-1 to Drive Macrophage-Mediated Ferroptosis in Papillary Thyroid Carcinoma. [PDF]

Cancer Med
Niu Y, Yao Z, Zhang M, Zhang J, Li Y, Xie J, Zhou Z.   +6 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The imprinted Peg3 gene is a potent regulator of the DNA methylome in trophoblast cells. [PDF]

Stem Cell Reports
Kokorudz C, Ballasy N, Radford BN, Jadli AS, Krala A, Narang A, Dean W, Hemberger M.   +7 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Non-geographical population structure of malaria vector Anopheles gambiae and Anopheles coluzzii but weak structure in Anopheles arabiensis within Burkina Faso: Implications for vector control and gene drive implementation

Kaboré H, Brenas J, Kientega M, Traoré N, Pescod P, Sawadogo G, Koutoucheva AH, Lanfancotti A, Namountougou M, Maiga H, Nolan T, Miles A, Clarkson CS, Diabaté A.   +13 more
europepmc   +1 more source