Results 131 to 140 of about 3,440,639 (300)

Remote Activation of Wnt Signaling and Cell Proliferation by E‐Cadherin Magnetomechanical Stimulation

Advanced Functional Materials, EarlyView.
A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Christian Castro‐Hinojosa, Pablo Martínez‐Vicente, Lucía G. Recaredo, Susel Del Sol‐Fernández, Pilar Gomollón‐Zueco, Yilian Fernández‐Afonso, Raluca M. Fratila, María Moros   +7 more
wiley   +1 more source

Efficient genome-scale phylogenetic analysis under the duplication-loss and deep coalescence cost models

BMC Bioinformatics, 2010
Background Genomic data provide a wealth of new information for phylogenetic analysis. Yet making use of this data requires phylogenetic methods that can efficiently analyze extremely large data sets and account for processes of gene evolution, such as ...
Burleigh J Gordon, Bansal Mukul S, Eulenstein Oliver   +2 more
doaj   +1 more source

Tissue specificity follows gene duplication

International audienceA comparative transcriptomic analysis of eight tissue types in twenty bilaterian species reveals the long-lasting effects of genome duplication on the evolution of novel tissue-specific gene-expression ...
Necsulea, Anamaria
core   +1 more source

Selection-Driven Divergence After Gene Duplication in Arabidopsis thaliana

, 2011
Goßmann T, Schmid KJ. Selection-Driven Divergence After Gene Duplication in Arabidopsis thaliana. Journal of Molecular Evolution.
Goßmann, Toni ; https://orcid.org/, Schmid, Karl J., Karl J. Schmid, Toni I. Gossmann   +3 more
core   +1 more source

Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms

Advanced Functional Materials, EarlyView.
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger, Min Jiang, Florian Belger, Fabian Link, Benjamin Winkeljann, Olivia M. Merkel   +5 more
wiley   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Duplication of the prothrombin gene is associated with a significant increase in thrombin generation

Research and Practice in Thrombosis and Haemostasis
Background: Prothrombin gene mutations can be associated with either a thrombotic or a bleeding risk. Genomic studies and coagulation workup can provide valuable information to better understand their clinical importance.
Annelie Siegemund, Thomas Siegemund, Hagen Bönigk, Kristina Schlosser, Katja Konn, Sabine Keil, Sirak Petros   +6 more
doaj   +1 more source

An Engineered Thio‐Amino Polymer Achieves Potent, Safe, and Broad Cell Type Delivery in the Lung Mapped by Spatial Transcriptomics

Advanced Materials, EarlyView.
Synthesis and screening of a polymer library produced a versatile and inhalable mRNA vehicle for the lungs (P81). Compared to a published LNP, P81 provides increased delivery efficacy, achieving widespread expression in broad cell types, with no toxicity.
Pramodkumar EK, Younghun Jung, Elex S. Rose, Jae Yeon Joo, James R. Rose, José A. F. Assumpção, Hyeyoon Jeong, Lorena C. S. Chaves, Blake Andrew Miller, João Paulo Pera Mendes, Hannah E. Peck, Charmy J. Patel, Loren E. Sasser, Heather Pathak, Varun V. Mosur, Jaehyeon Hwang, Guilherme de Oliveira Lopes, Merrilee Thoresen, Santiago Cornejo, Peres Badial, Alicia Olivier, Amelia R. Woolums, Samuele Stazzoni, Noemi Manganaro, Eleonora Nencini, Giulio Pierleoni, Emanuele Andreano, Rino Rappuoli, Nichole Orr‐Burks, Sarah R. Hosking, Nicholas S. Heaton, Eric R. Lafontaine, Robert J. Hogan, Francois Villinger, Daryll Vanover, Chiara Zurla, Philip J. Santangelo   +36 more
wiley   +1 more source

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

Advanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi   +4 more
wiley   +1 more source

Models for the retention of duplicate genes and their biological underpinnings [version 2; peer review: 2 approved]

F1000Research
Gene content in genomes changes through several different processes, with gene duplication being an important contributor to such changes. Gene duplication occurs over a range of scales from individual genes to whole genomes, and the dynamics of this ...
Amanda E. Wilson, David A. Liberles, Malgorzata M. O'Reilly, Gavin Conant, Barbara Holland, Raquel Assis   +5 more
doaj   +1 more source