Results 111 to 120 of about 194,146 (309)

Gene-interleaving patterns of synteny in the genome: are they proof of an ancient genome duplication event?-4 [PDF]

, 2011
Copyright information:Taken from "Gene-interleaving patterns of synteny in the genome: are they proof of an ancient genome duplication event?"http://www.biology-direct.com/content/2/1/23Biology Direct 2007;2():23-23.Published online 25 Sep 2007PMCID ...
Elizabeth A Ruedi (82815), Gustavo Caetano-Anollés (65405), Nicolas Martin (82814), Feng-Jie Sun (82816), Richard LeDuc (5070)   +4 more
core   +1 more source

Evolution of cytochrome P450 gene superfamily in different cellular organisms

Frontiers in Ecology and Evolution
Cytochrome P450 enzymes, a widespread monooxygenase superfamily, are crucial for metabolic diversity and environmental adaptation. However, systematic analysis and comparison of the expansion of the P450 gene superfamily and its potential mechanisms in ...
Yuxia Shi, Yuxia Shi, Shu Zong, Shu Zong, Hejian Zhang, Hejian Zhang, Shuo Liu, Shuo Liu, Junru Yang, Lina Lu, Xiaonan Liu, Xiaonan Liu, Jian Cheng, Huifeng Jiang   +13 more
doaj   +1 more source

Gene and Genome Duplication in Spiders

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution
ABSTRACT Gene and genome duplications are widely observed across various organisms, including plants, yeasts, and animals. Numerous studies link gene duplications to the emergence of novel phenotypes, supporting the hypothesis that duplication events are advantageous for adaptive evolution.
Chetan Munegowda, Matthias Pechmann, Nikola‐Michael Prpic‐Schäper, Natascha Turetzek   +3 more
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Simulating Evolution by Gene Duplication [PDF]

Genetics, 1987
ABSTRACT By considering the recent finding that unequal crossing over and other molecular interactions are contributing to the evolution of multigene families, a model of the origin of repetitive genes was studied by Monte Carlo simulations.
openaire   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Diversification of Non-TIR Class NB-LRR Genes in Relation to Whole-Genome Duplication Events in Arabidopsis

Molecular Plant-Microbe Interactions, 2005
Arabidopsis thaliana is believed to have experienced at least two and possibly three whole-genome duplication events in its evolutionary history. In order to investigate the evolutionary relationships between these duplication events and diversification ...
Kan Nobuta, Tom Ashfield, Sun Kim, Roger W. Innes   +3 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Investigating the cellular and molecular mechanisms involved in establishing and maintaining centrosome asymmetry in Drosophila neuroblasts [PDF]

, 2015
Centrosome asymmetry has been implicated in stem cell fate maintenance in both flies and vertebrates. Drosophila neuroblasts, the neural precursors of the fly’s central nervous system, contain molecularly and physically asymmetric centrosomes.
Nair, Anjana Ramdas
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source