Results 101 to 110 of about 3,440,639 (300)

Divergent roles of CprK paralogues from Desulfitobacterium hafniense in activating gene expression [PDF]

, 2008
Gene duplication and horizontal gene transfer play an important role in the evolution of prokaryotic genomes. We have investigated the role of three CprK paralogues from the cAMP receptor protein-fumarate and nitrate reduction regulator (CRP-FNR) family ...
Vos, W.M., de, Smidt, H., Gabor, K., Sene, K.H., Oost, J., van der   +4 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Intrinsic adaptive value and early fate of gene duplication revealed by a bottom-up approach

eLife, 2018
The population genetic mechanisms governing the preservation of gene duplicates, especially in the critical very initial phase, have remained largely unknown.
Guillermo Rodrigo, Mario A Fares
doaj   +1 more source

GBS‐MeDIP: A method for the simultaneous identification of genetic and epigenetic variants in tumors

FEBS Open Bio, EarlyView.
GBS‐MeDIP combines DNA sequencing with enrichment of methylated DNA to profile genetic and epigenetic variation in the same reduced genomic fraction. Applied to gastric cancer and parathyroid tumors, it identifies sequence variants, copy number changes, and differentially methylated regions together, helping distinguish true epigenetic changes from ...
Fábio Pértille, Shiva Rezaei, Julia Uffenorde, Oliver Gimm, Mohammad Ali Hosseinpour Feizi, Luiz Lehmann Coutinho, Carlos Guerrero‐Bosagna   +6 more
wiley   +1 more source

Familial Lymphoproliferative Malignancies and Tandem Duplication of NF1 Gene

Case Reports in Oncological Medicine, 2014
Background. Neurofibromatosis type 1 is a genetic disorder caused by loss-of-function mutations in a tumor suppressor gene (NF1) which codifies the protein neurofibromin.
Gustavo Fernandes, Mirela Souto, Frederico Costa, Edite Oliveira, Bernardo Garicochea   +4 more
doaj   +1 more source

Gene duplication and the birthday problem [PDF]

Nature, 1982
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/62607/1/296176a0 ...
openaire   +3 more sources

DNA methylation signatures of duplicate gene evolution in angiosperms

, 2023
Gene duplication is a source of evolutionary novelty. DNA methylation may play a role in the evolution of duplicate genes through its association with gene expression.
Niederhuth, Chad
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Evolution of cytochrome P450 gene superfamily in different cellular organisms

Frontiers in Ecology and Evolution
Cytochrome P450 enzymes, a widespread monooxygenase superfamily, are crucial for metabolic diversity and environmental adaptation. However, systematic analysis and comparison of the expansion of the P450 gene superfamily and its potential mechanisms in ...
Yuxia Shi, Yuxia Shi, Shu Zong, Shu Zong, Hejian Zhang, Hejian Zhang, Shuo Liu, Shuo Liu, Junru Yang, Lina Lu, Xiaonan Liu, Xiaonan Liu, Jian Cheng, Huifeng Jiang   +13 more
doaj   +1 more source

Gene duplication and the evolution of moonlighting proteins

Frontiers in Genetics, 2015
Gene duplication is a recurring phenomenon in genome evolution and a major driving force in the gain of biological functions. Here, we examine the role of gene duplication in the origin and maintenance of moonlighting proteins, with special focus on ...
Adriana eEspinosa-Cantú, Diana eAscencio, Francisco eBarona-Gómez, Alexander eDeLuna   +3 more
doaj   +1 more source