Results 171 to 180 of about 194,146 (309)

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Gene duplication is associated with gene diversification and potential neofunctionalization in lung cancer evolution. [PDF]

Genome Res
Ashford P, Frankell AM, Piszka Z, Pang CSM, Abbasian M, Bakir MA, Jamal-Hanjani M, McGranahan N, Swanton C, Orengo CA.   +9 more
europepmc   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

<i>ATG</i> gene duplication in vertebrates: evolutionary divergence and its functional implications. [PDF]

Autophagy
Zhang S, Koyama-Honda I, Hiratsuka D, Mizushima N.   +3 more
europepmc   +1 more source

1‐D Collocated Dual‐Gradient Sensory Fibers for Comprehensive Sensing and Decoding of Complex Human Motion and Physiology

Advanced Materials, EarlyView.
Coupled materials design enables a monolithic fiber that integrates complementary sensing regimes into a single wearable strand. By preserving informative signal features across subtle physiological deformation, large body motion, and mixed mechanical inputs, the dual‐gradient architecture generates synchronized, less redundant outputs that improve ...
Yunheum Lee, Sungha Jeon, Min Kim, Joonhee Won, Jinwook Yeo, Kyunghyun Jo, Soyeon Lee, Kieun Park, Yechan Yang, Chul Kim, Gun‐Hee Lee, Seunghwa Ryu, Sungho Jo, Seongjun Park   +13 more
wiley   +1 more source

Phylogenomics of Asgard archaea reveals a unique blend of prokaryotic-like horizontal transfer and eukaryotic-like gene duplication. [PDF]

Nat Commun
Manzano-Morales S, Gabaldón T.
europepmc   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Ancient but dynamic: structural expansion, massive gene duplication, and transposable element colonization in a supergene controlling ant social organization. [PDF]

Mol Biol Evol
Boulain H, Deshmukh R, Avril A, Blacher P, Bourquin M, Yek SH, Zahnd S, Tran Van P, Chapuisat M.   +8 more
europepmc   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Straight outta clusters: differing gene duplication patterns for alkaloid biosynthesis and floral traits in California poppy. [PDF]

Plant Cell
Sun L.
europepmc   +1 more source