Results 221 to 230 of about 178,249 (266)
Some of the next articles are maybe not open access.
Gene Duplication and Gene Loading
2014During the early evolution of life, gene duplication, the production of two copies of a DNA sequence, allowed the rapid diversification of enzymatically catalyzed reactions and an increase in genome size, providing also material for the invention of new enzymatic properties and complex regulatory and developmental patterns. A duplication may involve (i)
openaire +2 more sources
The evolutionary demography of duplicate genes
Journal of Structural and Functional Genomics, 2003Although gene duplication has generally been viewed as a necessary source of material for the origin of evolutionary novelties, the rates of origin, loss, and preservation of gene duplicates are not well understood. Applying steady-state demographic techniques to the age distributions of duplicate genes censused in seven completely sequenced genomes ...
Michael, Lynch, John S, Conery
openaire +2 more sources
Gene Duplication and the Evolution of Enzymes
Nature, 1968The relationship between structure and function of proteins makes it unlikely that a new enzyme activity can evolve unless the genome contains extra DNA with suitable coding properties such as is provided by the duplication of a gene for a functionally related enzyme.
R L, Watts, D C, Watts
openaire +2 more sources
Preservation of duplicate genes by originalization
Genetica, 2008Neofunctionalization, subfunctionalization and increasing gene dosage were proposed to be the possible ways to explain duplicate-gene preservation in previous studies. However, in some natural populations, such as yeast Saccharomyces cerevisiae, a considerable proportion of the duplicate genes originated from ancient whole genomic duplication (WGD) is ...
Cheng, Xue, Yunxin, Fu
openaire +2 more sources
On the Multiple Gene Duplication Problem
1998A fundamental problem in computational biology is the determination of the correct species tree for a set of taxa given a set of (possibly contradictory) gene trees. In recent literature, the DUPLICATION/ LOSS model has received considerable attention. Here one measures the similarity/dissimilarity between a set of gene trees by counting the number of ...
Michael R. Fellows +2 more
openaire +1 more source
Detection of gene duplications and block duplications in eukaryotic genomes
Journal of Structural and Functional Genomics, 2003Several eukaryotic genomes have been completely sequenced and this provides an opportunity to investigate the extent and characteristics (e.g., single gene duplication, block duplication, etc.) of gene duplication in a genome. Detecting duplicate genes in a genome, however, is not a simple problem because of several complications such as domain ...
Wen-Hsiung, Li +3 more
openaire +2 more sources
2013
Due the sheer size and complexity of genomes, it is essential to develop automated methods to analyze them. To compare genomes, one distance measure that has been proposed is to determine the minimum number of evolutionary changes needed to transform one genome into another.
openaire +2 more sources
Due the sheer size and complexity of genomes, it is essential to develop automated methods to analyze them. To compare genomes, one distance measure that has been proposed is to determine the minimum number of evolutionary changes needed to transform one genome into another.
openaire +2 more sources
Seminars in Cell & Developmental Biology, 1999
The study of Hox gene clusters continues to serve as a paradigm for those interested in vertebrate genome evolution. Recent exciting discoveries about Hox gene composition in fishes challenges conventional views about vertebrate Hox gene evolution, and has initiated lively debates concerning the evolutionary events making the divergence of the major ...
openaire +2 more sources
The study of Hox gene clusters continues to serve as a paradigm for those interested in vertebrate genome evolution. Recent exciting discoveries about Hox gene composition in fishes challenges conventional views about vertebrate Hox gene evolution, and has initiated lively debates concerning the evolutionary events making the divergence of the major ...
openaire +2 more sources
Evidence for gene duplication in collagen
Journal of Molecular Biology, 1976The amino acid sequence of collagen α 1 chain has been compared with itself at various displacements to search for systematic and significant repeats. It shows regularities at intervals related to the stagger between adjacent triple-helical molecules in the fibril, at a distance D of 670 A or 78 (Gly-X-Y) triplets.
openaire +2 more sources
Role of gene duplication in evolution
Genome, 1989It is now known that many multigene and supergene families exist in eukaryote genomes: multigene families with uniform copy members like genes for ribosomal RNA, those with variable members like immunoglobulin genes, and supergene families such as those for various growth factor and hormone receptors.
openaire +2 more sources