Results 201 to 210 of about 178,249 (266)

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Genome-Wide Identification, Gene Duplication, and Expression Pattern of <i>NPC2</i> Gene Family in <i>Parnassius glacialis</i>. [PDF]

Genes (Basel)
Zhu Z, Su C, Guo X, Zhao Y, Nie R, He B, Hao J.   +6 more
europepmc   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Evolution, Gene Duplication, and Expression Pattern Analysis of CrRLK1L Gene Family in Zea mays (L.). [PDF]

Int J Mol Sci
Wang K, Xue B, He Y, Zhao H, Liu B, Jiang W, Jin P, Wang Y, Zhang X, He X.   +9 more
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Gene duplication and evolutionary plasticity of lin-12/Notch gene function in Caenorhabditis. [PDF]

Genetics
Lyu H, Moya ND, Andersen EC, Chamberlin HM.   +3 more
europepmc   +1 more source

Gene duplication, translocation and molecular evolution of Dmrt1 and related sex-determining genes in anurans

Shinde SS, Veltsos P, Ma W.
europepmc   +1 more source

Multi-gene duplication removal in an engineered human cellular MECP2 duplication syndrome model with an IRAK1-MECP2 duplication. [PDF]

Mol Ther Nucleic Acids
Rizvi SZ, Chan WS, Maino E, Steiman S, Forguson G, Klepfish M, Cohn RD, Ivakine EA.   +7 more
europepmc   +1 more source

Lineage-specific gene duplication and expansion of DUF1216 gene family in Brassicaceae. [PDF]

PLoS One
Zhang ZB, Xiong T, Wang XJ, Chen YR, Wang JL, Guo CL, Ye ZY.   +6 more
europepmc   +1 more source

The link between gene duplication and divergent patterns of gene expression across a complex life cycle. [PDF]

Evol Lett
DuBose JG, de Roode JC.
europepmc   +1 more source