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Human Mutation, 2006
The detection of duplications in Duchenne (DMD)/Becker Muscular Dystrophy (BMD) has long been a neglected issue. However, recent technological advancements have significantly simplified screening for such rearrangements. We report here the detection and analysis of 118 duplications in the DMD gene of DMD/BMD patients.
S J, White +9 more
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The detection of duplications in Duchenne (DMD)/Becker Muscular Dystrophy (BMD) has long been a neglected issue. However, recent technological advancements have significantly simplified screening for such rearrangements. We report here the detection and analysis of 118 duplications in the DMD gene of DMD/BMD patients.
S J, White +9 more
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Duplicated homeobox genes in Xenopus
Developmental Biology, 1989Multiple kinds of clones and restriction fragment polymorphisms are frequently encountered when analyzing genes of the tetraploid frog Xenopus laevis. Two types of cDNA clone have been isolated for homeobox gene 2. Analysis of their corresponding genomic clones confirmed the existence of clearly distinct restriction maps; in addition the nearby ...
A F, Fritz +4 more
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Gene Duplication and Gene Loading
2014During the early evolution of life, gene duplication, the production of two copies of a DNA sequence, allowed the rapid diversification of enzymatically catalyzed reactions and an increase in genome size, providing also material for the invention of new enzymatic properties and complex regulatory and developmental patterns. A duplication may involve (i)
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Gene Duplication and Evolution
Science, 2002Abstract Motivated in part by Ohno’s (1970) influential book, substantial attention has been given to the idea that gene duplication is a major mechanism for the origin of new gene functions. A theoretical population genetic framework for understanding the evolutionary mechanisms responsible for the success versus demise of gene ...
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Current Opinion in Genetics & Development, 2001
Genomic sequencing projects have revealed the productivity of processes duplicating genes or entire chromosome segments. Substantial proportions of the yeast, Arabidopsis and human gene complements are made up of duplicates. This has prompted much interest in the processes of duplication, functional divergence and loss of genes, has renewed the debate ...
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Genomic sequencing projects have revealed the productivity of processes duplicating genes or entire chromosome segments. Substantial proportions of the yeast, Arabidopsis and human gene complements are made up of duplicates. This has prompted much interest in the processes of duplication, functional divergence and loss of genes, has renewed the debate ...
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Analysing gene function after duplication
BioEssays, 2001AbstractAfter gene duplication, mutations cause the gene copies to diverge. The classical model predicts that these mutations will generally lead to the loss of function of one gene copy; rarely, new functions will be created and both duplicate genes are conserved.
T, Massingham, L J, Davies, P, Liò
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Expression divergence between duplicate genes
Trends in Genetics, 2005A general picture of the role of expression divergence in the evolution of duplicate genes is emerging, thanks to the availability of completely sequenced genomes and functional genomic data, such as microarray data. It is now clear that expression divergence, regulatory-motif divergence and coding-sequence divergence all increase with the age of ...
Wen-Hsiung, Li, Jing, Yang, Xun, Gu
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Venom evolution through gene duplications
Gene, 2012Venoms contain highly complex mixtures that typically include hundreds of different components and have evolved independently in a diverse range of animals including platypuses, shrews, snakes, lizards, fishes, echinoderms, spiders, wasps, centipedes, sea snails, cephalopods, jellyfish and sea anemones. Many venom genes evolved through gene duplication.
Wong, Emily S. W., Belov, Katherine
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Horizontal gene transfers as metagenomic gene duplications
Molecular BioSystems, 2012While it is well accepted that horizontal gene transfer plays an important role in the evolution and the diversification of prokaryotic genomes, many questions remain open regarding its functional mechanisms of action and its interplay with the extant genome.
Grassi L +3 more
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Zinc finger gene clusters and tandem gene duplication
Proceedings of the fifth annual international conference on Computational biology, 2001Zinc finger genes in mammalian genomes are frequently found to occur in clusters with cluster members appearing in a tandem array on the chromosome. It has been suggested that in situ gene duplication events are primarily responsible for the evolution of such clusters.
Mengxiang, Tang +2 more
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