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Gene Duplication and Evolution
Science, 2002Abstract Motivated in part by Ohno’s (1970) influential book, substantial attention has been given to the idea that gene duplication is a major mechanism for the origin of new gene functions. A theoretical population genetic framework for understanding the evolutionary mechanisms responsible for the success versus demise of gene ...
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Current Opinion in Genetics & Development, 2001
Genomic sequencing projects have revealed the productivity of processes duplicating genes or entire chromosome segments. Substantial proportions of the yeast, Arabidopsis and human gene complements are made up of duplicates. This has prompted much interest in the processes of duplication, functional divergence and loss of genes, has renewed the debate ...
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Genomic sequencing projects have revealed the productivity of processes duplicating genes or entire chromosome segments. Substantial proportions of the yeast, Arabidopsis and human gene complements are made up of duplicates. This has prompted much interest in the processes of duplication, functional divergence and loss of genes, has renewed the debate ...
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Gene Duplication and Gene Loading
2014During the early evolution of life, gene duplication, the production of two copies of a DNA sequence, allowed the rapid diversification of enzymatically catalyzed reactions and an increase in genome size, providing also material for the invention of new enzymatic properties and complex regulatory and developmental patterns. A duplication may involve (i)
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The evolutionary demography of duplicate genes
Journal of Structural and Functional Genomics, 2003Although gene duplication has generally been viewed as a necessary source of material for the origin of evolutionary novelties, the rates of origin, loss, and preservation of gene duplicates are not well understood. Applying steady-state demographic techniques to the age distributions of duplicate genes censused in seven completely sequenced genomes ...
Michael, Lynch, John S, Conery
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Gene Duplication and the Evolution of Enzymes
Nature, 1968The relationship between structure and function of proteins makes it unlikely that a new enzyme activity can evolve unless the genome contains extra DNA with suitable coding properties such as is provided by the duplication of a gene for a functionally related enzyme.
R L, Watts, D C, Watts
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Duplicated homeobox genes in Xenopus
Developmental Biology, 1989Multiple kinds of clones and restriction fragment polymorphisms are frequently encountered when analyzing genes of the tetraploid frog Xenopus laevis. Two types of cDNA clone have been isolated for homeobox gene 2. Analysis of their corresponding genomic clones confirmed the existence of clearly distinct restriction maps; in addition the nearby ...
A F, Fritz +4 more
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Preservation of duplicate genes by originalization
Genetica, 2008Neofunctionalization, subfunctionalization and increasing gene dosage were proposed to be the possible ways to explain duplicate-gene preservation in previous studies. However, in some natural populations, such as yeast Saccharomyces cerevisiae, a considerable proportion of the duplicate genes originated from ancient whole genomic duplication (WGD) is ...
Cheng, Xue, Yunxin, Fu
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Detection of gene duplications and block duplications in eukaryotic genomes
Journal of Structural and Functional Genomics, 2003Several eukaryotic genomes have been completely sequenced and this provides an opportunity to investigate the extent and characteristics (e.g., single gene duplication, block duplication, etc.) of gene duplication in a genome. Detecting duplicate genes in a genome, however, is not a simple problem because of several complications such as domain ...
Wen-Hsiung, Li +3 more
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2013
Due the sheer size and complexity of genomes, it is essential to develop automated methods to analyze them. To compare genomes, one distance measure that has been proposed is to determine the minimum number of evolutionary changes needed to transform one genome into another.
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Due the sheer size and complexity of genomes, it is essential to develop automated methods to analyze them. To compare genomes, one distance measure that has been proposed is to determine the minimum number of evolutionary changes needed to transform one genome into another.
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Seminars in Cell & Developmental Biology, 1999
The study of Hox gene clusters continues to serve as a paradigm for those interested in vertebrate genome evolution. Recent exciting discoveries about Hox gene composition in fishes challenges conventional views about vertebrate Hox gene evolution, and has initiated lively debates concerning the evolutionary events making the divergence of the major ...
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The study of Hox gene clusters continues to serve as a paradigm for those interested in vertebrate genome evolution. Recent exciting discoveries about Hox gene composition in fishes challenges conventional views about vertebrate Hox gene evolution, and has initiated lively debates concerning the evolutionary events making the divergence of the major ...
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