Results 341 to 350 of about 8,339,405 (403)

Mitochondrial gene editing

Nature Reviews Methods Primers, 2023
Wendy K. Shoop, Sandra R. Bacman, Jose Domingo Barrera-Paez, Carlos T. Moraes   +3 more
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A DNA Origami-Based Gene Editing System for Efficient Gene Therapy in Vivo.

Angewandte Chemie, 2023
DNA nanostructures have played an important role in the development of novel drug delivery systems. Herein, we report a DNA origami-based CRISPR/Cas9 gene editing system for efficient gene therapy in vivo.
Wantao Tang, Ting Tong, Hong Wang, Xuehe Lu, Changping Yang, Yushuai Wu, Yuang Wang, Jianbing Liu, Baoquan Ding   +8 more
semanticscholar   +1 more source

Engineered Nanomaterials to Potentiate CRISPR/Cas9 Gene Editing for Cancer Therapy

Advances in Materials, 2023
Clustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/Cas9) gene‐editing technology shows promise for manipulating single or multiple tumor‐associated genes and engineering immune cells to treat cancers.
Ke Yi, Huimin Kong, Yeh-Hsing Lao, Di Li, Rachel L. Mintz, T. Fang, Guojun Chen, Yu Tao, Mingqiang Li, Jianxun Ding   +9 more
semanticscholar   +1 more source

Gene Editing

2023
Gene editing allows scientists to modify an organism's DNA with unparalleled precision, utilizing techniques like CRISPR-Cas9. It aids researchers to target specific genes, enhance desirable traits, correct genetic disorders, and develop innovative therapies.
openaire   +2 more sources

Gene Editing for CEP290-Associated Retinal Degeneration.

New England Journal of Medicine
BACKGROUND CEP290-associated inherited retinal degeneration causes severe early-onset vision loss due to pathogenic variants in CEP290. EDIT-101 is a clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9 ...
Eric A. Pierce, Tomas S Aleman, K. Jayasundera, Bright S. Ashimatey, Keunpyo Kim, Alia Rashid, Michael C. Jaskolka, Rene L Myers, Byron L. Lam, Steven T Bailey, Jason I. Comander, A. Lauer, Albert M. Maguire, M. Pennesi   +13 more
semanticscholar   +1 more source

Injectable Microgels with Hybrid Exosomes of Chondrocyte‐Targeted FGF18 Gene‐Editing and Self‐Renewable Lubrication for Osteoarthritis Therapy

Advances in Materials
Abnormal silencing of fibroblast growth factor (FGF) signaling significantly contributes to joint dysplasia and osteoarthritis (OA); However, the clinical translation of FGF18‐based protein drugs is hindered by their short half‐life, low delivery ...
Manyu Chen, Yan Lu, Yuhan Liu, Quanying Liu, Siyan Deng, Yuan Liu, Xiaolin Cui, Jie Liang, Xingdong Zhang, Yujiang Fan, Qiguang Wang   +10 more
semanticscholar   +1 more source

CRISPR-GPT for agentic automation of gene-editing experiments.

Nature Biomedical Engineering
Performing effective gene-editing experiments requires a deep understanding of both the CRISPR technology and the biological system involved. Meanwhile, despite their versatility and promise, large language models (LLMs) often lack domain-specific ...
Yuanhao Qu, Kaixuan Huang, Ming Yin, Kanghong Zhan, Dyllan Liu, Di Yin, H. Cousins, William A. Johnson, Xiaotong Wang, Mihir Shah, R. Altman, Denny Zhou, Mengdi Wang, Le Cong   +13 more
semanticscholar   +1 more source

Hypoxia-Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild-Photothermal Therapy.

Angewandte Chemie, 2021
Near-infrared (NIR)-light-triggered photothermal therapy (PTT) is usually associated with an undesirable heating damage to normal organs nearby due to its high temperature (>50 o C) for available tumor ablation.
Xueqing Li, Yongchun Pan, Chao Chen, Yanfeng Gao, Xinli Liu, Kaiyong Yang, Xiaowei Luan, Dongtao Zhou, Fei Zeng, Xin Han, Yujun Song   +10 more
semanticscholar   +1 more source

Gene Edited Seeds

Outlooks on Pest Management, 2023
The European Union is finally coming around to gene-edited seeds For a quarter century, activists such as Vandana Shiva have opposed GM crops that can help feed the world. Now, more than ever, it is time to reject their Luddite demands. In 2021, the European Union announced that it would be reviewing its 2001-era legislation governing genetically ...
openaire   +1 more source