Results 121 to 130 of about 191,482 (312)

Comparing several approaches for hierarchical classification of proteins with decision trees [PDF]

, 2007
Proteins are the main building blocks of the cell, and perform almost all the functions related to cell activity. Despite the recent advances in Molecular Biology, the function of a large amount of proteins is still unknown. The use of algorithms able to
Carvalho, Andre C. P. L. F., Holden, Nicholas, Costa, Eduardo P., Lorena, Ana C., Freitas, Alex A.   +4 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Improving the performance of the iterative signature algorithm for the identification of relevant patterns

, 2011
The iterative signature algorithm (ISA) has become very attractive to detect co-regulated genes from microarray data matrices and can be a useful tool for the identification of similar patterns in many other kinds of numerical data matrices. Nevertheless,
Oliveira, J.L., Pinheiro, M., J. L. Oliveira, V. Afreixo, A. Freitas, M. Pinheiro, G. Moura, M. Santos, Moura, G., Santos, M., Freitas, A., Afreixo, V.   +11 more
core   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

T2prhd: a tool to study the patterns of repeat evolution [PDF]

, 2008
BACKGROUND: The models developed to characterize the evolution of multigene families (such as the birth-and-death and the concerted models) have also been applied on the level of sequence repeats inside a gene/protein.
Andó István, István Andó, Pénzes, Zsolt, Andó, István, Sipos Botond, Botond Sipos, Zsolt Pénzes, Somogyi Kálmán, Somogyi, Kálmán, Sipos, Botond, Kálmán Somogyi, Pénzes Zsolt   +11 more
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

A hybrid EKF and switching PSO algorithm for joint state and parameter estimation of lateral flow immunoassay models

, 2012
This is the post-print version of the Article. The official published can be accessed from the link below - Copyright @ 2012 IEEEIn this paper, a hybrid extended Kalman filter (EKF) and switching particle swarm optimization (SPSO) algorithm is proposed ...
Zidong Wang, Min Du, Zeng, N, Liu, X, Wang, Z, Nianyin Zeng, Xiaohui Liu, Li, Y, Yurong Li, Du, M   +9 more
core   +1 more source

Intrinsic noise analyzer:a software package for the exploration of stochastic biochemical kinetics using the system size expansion [PDF]

, 2012
The accepted stochastic descriptions of biochemical dynamics under well-mixed conditions are given by the Chemical Master Equation and the Stochastic Simulation Algorithm, which are equivalent.
Matuschek, H, Thomas, Philipp, Ramon Grima, Matuschek, Hannes, Thomas Philipp, Grima Ramon, Thomas, P, Philipp Thomas, Hannes Matuschek, Grima, Ramon, Matuschek Hannes, Grima, Ramon; id_orcid, Grima, R   +12 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Multiple sequence alignment with the Divide-and-Conquer method.

, 1998
Stoye J. Multiple sequence alignment with the Divide-and-Conquer method. Gene. 1998;211(2):GC45-GC56.An improved algorithm for the simultaneous alignment of multiple protein and nucleic acid sequences, the Divide-and-Conquer Alignment procedure (DCA), is
Jens Stoye, Stoye, Jens ; https://orcid.org/   +1 more
core   +1 more source