Results 111 to 120 of about 13,983,545 (429)

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, EarlyView.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source

Sorting and packaging of RNA into extracellular vesicles shape intracellular transcript levels

BMC Biology, 2022
Background Extracellular vesicles (EVs) are released by nearly every cell type and have attracted much attention for their ability to transfer protein and diverse RNA species from donor to recipient cells.
Tina O’Grady, Makon-Sébastien Njock, Michelle Lion, Jonathan Bruyr, Emeline Mariavelle, Bartimée Galvan, Amandine Boeckx, Ingrid Struman, Franck Dequiedt   +8 more
doaj   +1 more source

The influence of gene expression time delays on Gierer-Meinhardt pattern formation systems [PDF]

, 2010
There are numerous examples of morphogen gradients controlling long range signalling in developmental and cellular systems. The prospect of two such interacting morphogens instigating long range self-organisation in biological systems via a Turing ...
A. Eldar, A. Gierer, A. Sorkin, A. Turing, A. Wells, A.F. Schier, A.J. Koch, B. Alberts, C. Varea, C.B. Kimmel, C.L. Roy, C.M. Stoscheck, C.N. Tennyson, E. A. Gaffney, E. Piddini, E.A. Gaffney, E.J. Crampin, E.M. Rauch, E.V. Entchev, H. Juan, H.S. Jung, J. Bard, J. Lewis, J. Schnakenberg, J.A. Fischer, J.D. Murray, K.M. Page, K.W. Morton, L. Beguinot, L.A. Segel, L.S. Krezel, M. Baron, M.P. Harris, N. A. M. Monk, R. Iratini, R.E. Baker, S. Seirin Lee, S.R. Veflingstad, T. Miura, T. Miura, X.H. Jing, Y. Chen   +41 more
core   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source

Ironing out the conflicts: iron supplementation reduces negatives bacterial interactions in the rhizosphere of an Atacama-endemic perennial grass

Environmental Microbiome
Background In plants, root exudates selectively influence the growth of bacteria that colonize the rhizosphere. Bacterial communities associated with root systems are involved in macro and micronutrients cycling and organic matter transformation.
Constanza Aguado-Norese, Jonathan E. Maldonado, Christian Hodar, Gabriel Galvez, Daniel E. Palma, Verónica Cambiazo, Mauricio Gonzalez   +6 more
doaj   +1 more source

SAGA–CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity

Epigenetics & Chromatin, 2020
Background Histone H2B deubiquitination is performed by numerous deubiquitinases in eukaryotic cells including Ubp8, the catalytic subunit of the tetrameric deubiquitination module (DUBm: Ubp8; Sus1; Sgf11; Sgf73) of the Spt-Ada-Gcn5 acetyltransferase ...
Carme Nuño-Cabanes, Varinia García-Molinero, Manuel Martín-Expósito, María-Eugenia Gas, Paula Oliete-Calvo, Encar García-Oliver, María de la Iglesia-Vayá, Susana Rodríguez-Navarro   +7 more
doaj   +1 more source

Marker Genes for Anatomical Regions in the Brain: Insights from the Allen Gene Expression Atlas [PDF]

arXiv, 2011
Quantitative criteria are proposed to identify genes (and sets of genes) whose expression marks a specific brain region (or a set of brain regions). Gene-expression energies, obtained for thousands of mouse genes by numerization of in-situ hybridization images in the Allen Gene Expression Atlas, are used to test these methods in the mouse brain ...
arxiv  

Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B. [PDF]

, 2016
BackgroundUBE4B is an E3/E4 ubiquitin ligase whose gene is located in chromosome 1p36.22. We analyzed the associations of UBE4B gene and protein expression with neuroblastoma patient outcomes and with tumor prognostic features and histology.MethodsWe ...
Bean, Andrew J, Guo, Rong Jun, Hollingsworth, Emporia Faith, Indiviglio, Sandra, Ittmann, Michael, Liu, Yin, Lopez-Terrada, Dolores, Major, Angela M, Mo, Qianxing, Whittle, Sarah B, Woodfield, Sarah E, Zage, Peter E   +11 more
core   +2 more sources

MicroRNA gene expression deregulation in human breast cancer.

Cancer Research, 2005
MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed,
M. Iorio, M. Ferracin, Chang-gong Liu, A. Veronese, R. Spizzo, S. Sabbioni, E. Magri, M. Pedriali, M. Fabbri, M. Campiglio, S. Ménard, J. Palazzo, A. Rosenberg, P. Musiani, S. Volinia, I. Nenci, G. Calin, P. Querzoli, M. Negrini, C. Croce   +19 more
semanticscholar   +1 more source