Results 141 to 150 of about 13,983,545 (429)

Integrated signaling pathway and gene expression regulatory model to dissect dynamics of Escherichia coli challenged mammary epithelial cells [PDF]

, 2014
Cells transform external stimuli, through the activation of signaling pathways, which in turn activate gene regulatory networks, in gene expression. As more omics data are generated from experiments, eliciting the integrated relationship between the ...
den Breems, Nicoline Y., Kulasiri, Don, Nguyen, Lan K.   +2 more
core   +3 more sources

Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Array technologies have made it straightforward to monitor simultaneously the expression pattern of thousands of genes. The challenge now is to interpret such massive data sets.
P. Tamayo, D. Slonim, J. Mesirov, Q. Zhu, S. Kitareewan, E. Dmitrovsky, E. Lander, T. Golub   +7 more
semanticscholar   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Dualistic role of ZEB1 and ZEB2 in tumor progression

Biology Direct
It is generally accepted that ZEB1 and ZEB2 act as master regulators of the epithelial-mesenchymal transition, which arguably is the key mechanism of metastasis.
Sergey E. Parfenyev, Alexandra A. Daks, Oleg Y. Shuvalov, Olga A. Fedorova, Nikolay B. Pestov, Tatyana V. Korneenko, Nickolai A. Barlev   +6 more
doaj   +1 more source

Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading

Nature Communications, 2017
The cytokines IL-1β and IL-6 mediate the systemic acute phase response (APR). Here, the authors provide evidence that these cytokines lead to both synergistic and antagonistic gene expression during APR; synergistic induction occurs by assisted loading ...
Ido Goldstein, Ville Paakinaho, Songjoon Baek, Myong-Hee Sung, Gordon L. Hager   +4 more
doaj   +1 more source

Dynamics of gene expression under feedback [PDF]

arXiv, 2008
Gene expression is a stochastic process governed by the presence of specific transcription factors. Here we study the dynamics of gene expression in the presence of feedback, where a gene regulates its own expression. The nonlinear coupling between input and output of gene expression can generate a dynamics different from simple scenarios such as the ...
arxiv  

Aberrant behaviours of reaction diffusion self-organisation models on growing domains in the presence of gene expression time delays [PDF]

, 2010
Turing’s pattern formation mechanism exhibits sensitivity to the details of the initial conditions suggesting that, in isolation, it cannot robustly generate pattern within noisy biological environments.
A. Gierer, A. Louvi, A. Madzvamuse, A. Madzvamuse, A. Nakamasu, A. Neville, A. Sorkin, A. Turing, A. Wells, B. Alberts, B. Bunow, C. Varea, C.L. Roy, C.M. Stoscheck, C.N. Tennyson, D. Rogulja, E. A. Gaffney, E. Piddini, E.A. Gaffney, E.J. Crampin, E.J. Crampin, E.V. Entchev, H.G.E. Hentschel, J. Bard, J. Lewis, J. Schnakenberg, J.A. Fischer, J.D. Murray, K. Uriu, L. Beguinot, L. Solnica-Krezel, M. Abdreeff, M. Affolter, M. Alber, M.P. Harris, P. Arcuri, P.M. Kulesa, R. Dillon, R. Sakuma, S. Kondo, S. Kondo, S. Mukherjee, S. Newman, S. Seirin-Lee, S. Seirin Lee, T. Miura, T. Miura, T. Miura, W. Chang, W. Zeng, X.H. Jing, Y. Chen   +51 more
core   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Diagnosis of multiple cancer types by shrunken centroids of gene expression

Proceedings of the National Academy of Sciences of the United States of America, 2002
We have devised an approach to cancer class prediction from gene expression profiling, based on an enhancement of the simple nearest prototype (centroid) classifier.
R. Tibshirani, T. Hastie, B. Narasimhan, Gilbert Chu   +3 more
semanticscholar   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source