Results 191 to 200 of about 5,533,099 (347)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

AIRE's Complex Role Beyond Promiscuous Gene Expression. [PDF]

Immunol Rev
Peterson P.
europepmc   +1 more source

Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets.

, 1986
Patrick B. Iynedjian, G Möbius, H.J. Seitz, Claes B. Wollheim, Albert E. Renold   +4 more
openalex   +2 more sources

Comparing the Expression of Olfaction-Related Genes in Gypsy Moth (Lymantria dispar) Adult Females and Larvae from One Flightless and Two Flight-Capable Populations [PDF]

, 2017
Andrea Clavijo McCormick, Ewald Große‐Wilde, David A. Wheeler, Mark C. Mescher, Bill S. Hansson, Consuelo Μ. De Moraes   +5 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A conserved 3'UTR short motif regulates gene expression in vertebrates. [PDF]

Nucleic Acids Res
Eufrásio A, Machado J, Azevedo J, Pereira-Castro I, Ferreira A, Moutinho A, Henriques F, Jesus A, Araújo M, Tavares J, Sousa B, Cavadas B, Kessler IG, Teixeira J, Pinto PB, Bessa J, Moreira A.   +16 more
europepmc   +1 more source

Exploring terra incognita of cognitive science: Lateralization of gene expression at the frontal pole of the human brain [PDF]

, 2017
Irina A. Dolina, Olga Efimova, Evgeniy M. Kildyushov, Aleksey S. Sokolov, Philipp Khaitovich, Artem Nedoluzhko, Fedor Sharko, Boris M. Velichkovsky   +7 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Murine Coronavirus Delays Expression of a Subset of Interferon-Stimulated Genes

, 2010
Kristine M. Rose, Ruth Elliott, Luis Martínez‐Sobrido, Adolfo Garcı́a-Sastre, Susan R. Weiss   +4 more
openalex   +1 more source

The AtDREB1A transcription factor up-regulates expression of a vernalization pathway gene, GmVRN1-like, delaying flowering in soybean [PDF]

, 2016
Haicui Suo, Jing Lü, Qibin Ma, Cunyi Yang, Xiu-xiang Zhang, Xing Meng, Shangzhi Huang, Hai Nian   +7 more
openalex   +1 more source