Results 191 to 200 of about 14,519,680 (398)

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Cell, 2013
Lei S. Qi, Matthew H. Larson, Luke A. Gilbert, J. Doudna, J. Weissman, A. Arkin, W. Lim   +6 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

Protein & Cell, 2020
Paloma Martinez-Redondo, Isabel Guillen-Guillen, Noah Davidsohn, Chao Wang, Javier Prieto, Masakazu Kurita, Fumiyuki Hatanaka, Cuiqing Zhong, Reyna Hernandez-Benitez, Tomoaki Hishida, Takashi Lezaki, Akihisa Sakamoto, Amy N. Nemeth, Yuriko Hishida, Concepcion Rodriguez Esteban, Kensaku Shojima, Ling Huang, Maxim Shokhirev, Estrella Nuñez-Delicado, Josep M. Campistol, Isabel Guillen-Vicente, Elena Rodriguez-Iñigo, Juan Manuel Lopez-Alcorocho, Marta Guillen-Vicente, George Church, Pradeep Reddy, Pedro Guillen-Garcia, Guang-Hui Liu, Juan Carlos Izpisua Belmonte   +28 more
doaj   +1 more source

Effects of estrogen on gene expression in chick oviduct. The role of chromatin proteins in regulating transcription of the ovalbumin gene.

, 1976
Sophia Y. Tsai, Steven Edward Harris, Yun‐Li Ma, Bert W. O’Malley   +3 more
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Gene expression in vitro of colicin E1 plasmid

, 1979
Yousuke Ebina, Fumio Kishi, Teruko Nakazawa, Atsushi Nakazawa   +3 more
openalex   +2 more sources

A general method for maximizing the expression of a cloned gene. [PDF]

, 1979
Thomas M. Roberts, R Kacich, Mark Ptashne   +2 more
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Immunoglobulin heavy variable (IgHV) gene mutation and micro-RNA expression in Burkitt’s lymphoma at Moi Teaching and Referral Hospital in Western Kenya

, 1970
Isaac Ndede, Simeon Mining, Kirtika Patel, F. M. E. Wanjala, Constance Tenge   +4 more
openalex   +2 more sources

Type-C RNA Virus Gene Expression in Human Tissue [PDF]

, 1974
Mette Strand, J. T. August
openalex   +1 more source