Results 191 to 200 of about 3,053,094 (318)

Profiling gene expression [PDF]

Nature Biotechnology, 1999
openaire   +3 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Aiming for spatial and temporal control of gene expression. [PDF]

Elife
Igor Travisano S, Lien CL.
europepmc   +1 more source

THE RELATIVE INFLUENCE OF SEX OF PROGENY ON THE LETHAL EXPRESSION OF THE SONLESS GENE IN DROSOPHILA MELANOGASTER [PDF]

, 1972
James J Colaianne, A. E. Bell
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The multimodal neuroimaging signatures and gene expression profiles for adverse childhood experiences. [PDF]

BMC Med
Yu T, Zhao G, Sun Y, Lu Z, Liao Y, Yuan R, Kang Z, Feng X, Zhu Y, Guo J, Zhang Y, Yue W.   +11 more
europepmc   +1 more source

Expression of Klebsiella pneumoniae Nitrogen Fixation Genes in Nitrate Reductase Mutants of Escherichia coli

, 1977
Charles Kennedy, J. R. Postgate
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Concerted Actions of FoxO1 and PPARα in Hepatic Gene Expression and Metabolic Adaptation. [PDF]

Diabetes
Kitamoto T, Watanabe H, Miyachi Y, Miyabayashi M, Qiang L, Ajiro M, Yoshimi A, Maezawa Y, Yokote K, Accili D.   +9 more
europepmc   +1 more source

Regulatory function of simian virus 40 DNA replication for late viral gene expression.

, 1977
A. Graessmann, M. Graessmann, Christoph Mueller   +2 more
openalex   +1 more source