Results 351 to 360 of about 13,983,545 (429)

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

FEBS Open Bio, EarlyView.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

Epigenetic regulation of complement C1Q gene expression. [PDF]

Front Immunol
Pegoraro S, Balduit A, Mangogna A, Kishore U, Ricci G, Agostinis C, Bulla R.   +6 more
europepmc   +1 more source

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

FEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He, Guiyi Gong, Geovani Quijas, Simon Ming‐Yuen Lee, Ratan K. Chaudhuri, Krzysztof Bojanowski   +5 more
wiley   +1 more source

Spatio-temporal reconstruction of gene expression patterns in developing mice.

Development
Aviñó-Esteban L, Cardona-Blaya H, Sharpe J.   +2 more
europepmc   +1 more source

BMAL1 is a Critical Regulator of Sex-Specific Gene Expression in the Heart. [PDF]

Function (Oxf)
Dierickx P.
europepmc   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

An international observational study validating gene-expression sepsis immune subgroups. [PDF]

Crit Care
Antcliffe DB, Peronnet E, Pène F, Strålin K, Brealey D, Blein S, Cleaver R, Cronhjort M, Diehl JL, Voiriot G, Fleurie A, Lannsjö C, Lukaszewicz AC, Mårtensson J, Pham T, De Prost N, Ricard JD, Singer M, Terraz G, Timsit JF, Unge C, Vieillard-Baron A, Wahlin RR, Llitjos JF, Gordon AC.   +24 more
europepmc   +1 more source

Gene expression

Experientia, 1996
openaire   +2 more sources

NF-κB is a Central Regulator of Hypoxia-Induced Gene Expression

Shakir D, Batie M, Kwok C, Kenneth NS, Rocha S.   +4 more
europepmc   +1 more source