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Clinical Orthopaedics and Related Research, 2000
Gene therapy is the process whereby a therapeutic protein is synthesized from a DNA molecule (gene) that has been inserted into the cells. The goal is to produce the desired protein in the proper quantity in the proper location. Successful designing of vectors for gene therapy requires knowledge of gene structure and regulation.
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Gene therapy is the process whereby a therapeutic protein is synthesized from a DNA molecule (gene) that has been inserted into the cells. The goal is to produce the desired protein in the proper quantity in the proper location. Successful designing of vectors for gene therapy requires knowledge of gene structure and regulation.
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Science, 2006
To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells ...
J. Lamb +19 more
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To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells ...
J. Lamb +19 more
semanticscholar +1 more source
Green fluorescent protein as a marker for gene expression.
Science, 1994A complementary DNA for the Aequorea victoria green fluorescent protein (GFP) produces a fluorescent product when expressed in prokaryotic (Escherichia coli) or eukaryotic (Caenorhabditis elegans) cells. Because exogenous substrates and cofactors are not
M. Chalfie +5 more
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Annual Review of Genetics, 1970
A hormone is an effector molecule produced in low concentration by one cell which evokes a physiological response in another. In vertebrates, nu merous classes of chemically unrelated compounds such as polypeptides, amino acids, amines, fatty acid derivatives, and steroids have hormonal activity. Certain of these substances probably are themselves the
David W. Martin, Gordon M. Tomkins
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A hormone is an effector molecule produced in low concentration by one cell which evokes a physiological response in another. In vertebrates, nu merous classes of chemically unrelated compounds such as polypeptides, amino acids, amines, fatty acid derivatives, and steroids have hormonal activity. Certain of these substances probably are themselves the
David W. Martin, Gordon M. Tomkins
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Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray
Science, 1995A high-capacity system was developed to monitor the expression of many genes in parallel. Microarrays prepared by high-speed robotic printing of complementary DNAs on glass were used for quantitative expression measurements of the corresponding genes ...
M. Schena +3 more
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Mechanisms of Ageing and Development, 1993
Considerable amount of data has accumulated during the past few years showing several changes in gene expression as a function of age. However, the basic mechanism of aging still remains poorly understood. In this review, we have mainly analysed the data pertaining to the hypothesis that aging is associated with genetic instability and have attempted ...
Tatsuzo Oka +2 more
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Considerable amount of data has accumulated during the past few years showing several changes in gene expression as a function of age. However, the basic mechanism of aging still remains poorly understood. In this review, we have mainly analysed the data pertaining to the hypothesis that aging is associated with genetic instability and have attempted ...
Tatsuzo Oka +2 more
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Gene Expression in Lactobacilli
2003Lactobacilli have always occupied an important place in food production. Their properties are widely exploited all over the world, in particular, in the preparation of food products and beverages (Table 6.1). Lactic acid fermentation is one of the oldest techniques used for the preservation of highly perishable raw materials like milk, meat, and ...
Peter H. Pouwels, Stéphane Chaillou
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Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Science, 2016Spatial structure of RNA expression RNA-seq and similar methods can record gene expression within and among cells. Current methods typically lose positional information and many require arduous single-cell isolation and sequencing. Ståhl et al.
Patrik L. Ståhl +20 more
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2022
Gene expression enables cells to function and adapt by turning genetic information into proteins and other essential molecules. It dictates how a genetic plan, encoded in DNA, is translated into actionable instructions. This intricate process begins with transcription, where a segment of DNA is copied into messenger RNA (mRNA).
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Gene expression enables cells to function and adapt by turning genetic information into proteins and other essential molecules. It dictates how a genetic plan, encoded in DNA, is translated into actionable instructions. This intricate process begins with transcription, where a segment of DNA is copied into messenger RNA (mRNA).
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The expression of immunoglobulin genes
Immunology Today, 1988Abstract Transcription of antibody genes is restricted to lymphoid cells and is a process controlled by multiple DNA elements. However, modulation of expression during B-cell ontogeny is effected by post-transcriptional and post-translational processes.
Graham P. Cook, Michael S. Neuberger
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