Results 91 to 100 of about 809,277 (348)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Gene expression profiling during murine tooth development

Frontiers in Genetics, 2012
The aim of this study was to describe the expression of genes, including ameloblastin (Ambn), amelogenin X chromosome (Amelx) and enamelin (Enam) during early (pre-secretory) tooth development. The expression of these genes has predominantly been studied
Maria A dos Santos silva Landin, Maria A dos Santos silva Landin, Maziar eShabestari, Maziar eShabestari, Eshrat eBabaie, Janne Elin Reseland, Harald eOsmundsen   +6 more
doaj   +1 more source

NF-{kappa}B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [PDF]

, 2006
Activation of mammalian innate and acquired immune responses must be tightly regulated by elaborate mechanisms to control their onset and termination. MicroRNAs have been implicated as negative regulators controlling diverse biological processes at the ...
Baltimore, David, Boldin, Mark P., Chang, Kuang-Jung, Taganov, Konstantin D.   +3 more
core  

Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. [PDF]

, 2012
Expression of the cell-surface antigen CD10 has long been used to define the lymphoid commitment of human cells. Here we report a unique lymphoid-primed population in human bone marrow that was generated from hematopoietic stem cells (HSCs) before onset ...
Crooks, Gay M, Ge, Shundi, Hao, Qian-Lin, Kohn, Lisa A, Mikkola, Hanna KA, Parekh, Chintan, Sasidharan, Rajkumar, Zhu, Yuhua   +7 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Gene expression profiling in multiple sclerosis brain

Neurobiology of Disease, 2012
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system and the leading cause of non-traumatic neurological disability in young adults in the United States and Europe.
Ranjan Dutta, Bruce D. Trapp
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Gene expression profile of sprinter’s muscle

The FASEB Journal, 2007
We have characterized the global gene expression profile in left vastus lateralis muscles of sprinters and sedentary men. The gene expression profile was analyzed by using a serial analysis of gene expression (SAGE) method. The abundantly expressed transcripts in the sprinter’s muscle were mainly involved in contraction and energy metabolism whereas ...
M, Yoshioka, H, Tanaka, N, Shono, M, Shindo, J, St-Amand   +4 more
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Integrative Gene Expression Profiling Reveals That Dysregulated Triple microRNAs Confer Paclitaxel Resistance in Non-Small Cell Lung Cancer via Cotargeting MAPT [Corrigendum]

Cancer Management and Research, 2020
Cai Y, Jia R, Xiong H, et al. Cancer Manag Res. 2019;11:7391—7404. The authors have advised due to an error at the time of figure assembly, Figure 1D on page 7393 is incorrect. The correct Figure 1 is shown below.
Cai Y, Jia R, Xiong H, Ren Q, Zuo W, Lin T, Lin R, Lei Y, Wang P, Dong H, Zhao H, Zhu L, Fu Y, Zeng Z, Zhang W, Wang S   +15 more
doaj