Results 221 to 230 of about 2,789,846 (387)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Gene expression profiling in pure neural leprosy: insights into pathogenesis and diagnostic biomarkers. [PDF]

Front Immunol
de Athaide MM, Leal-Calvo T, Da Silva TP, Rosa TLSA, Ferreira H, Pascarelli BMO, Siquara de Sousa AC, Jardim MR, Pinheiro RO.   +8 more
europepmc   +1 more source

Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle

Science, 2003
K. Roch, Yingyao Zhou, P. Blair, M. Grainger, J. K. Moch, J. Haynes, P. D. L. Vega, A. Holder, S. Batalov, D. Carucci, E. Winzeler, E. Winzeler   +11 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Profiling viral gene expression in lymphomas

Brazilian Journal of Infectious Diseases
Dirk P. Dittmer
doaj   +1 more source

Gene expression profiling of SPIN1 in gastric cancer: insights into tumorigenesis and potential therapeutic targets. [PDF]

Front Genet
Lv BB, Cai L, Xiao Y, Wang RH, Lin XY.
europepmc   +1 more source

Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast [PDF]

, 2001
Krishnamurthy Natarajan, Michael R. Meyer, Belinda M. Jackson, David Slade, Christopher J. Roberts, Alan G. Hinnebusch, Matthew J. Marton   +6 more
openalex   +1 more source

Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets.

Blood, 2011
K. Wong, J. J. Tai, Wing-Cheong Wong, H. Han, X. Sem, W. Yeap, P. Kourilsky, S. Wong   +7 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Lipidome and Gene Expression Profiling in Zebrafish Liver Spheroids: A 3D Model for Environmental Toxicology Applications. [PDF]

Environ Sci Technol
Wang T, Perelló Amorós M, Porte C.
europepmc   +1 more source