Enhanced Th17 Responses in Patients with Autoimmune Hepatitis
Middle East Journal of Digestive Diseases, 2019 BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease.
Farinaz Behfarjam +2 more
doaj +1 more source
Moderate alcohol consumption alters both leucocyte gene expression profiles and circulating proteins related to immune response and lipid metabolism in men [PDF]
Moderate alcohol consumption has various effects on immune and inflammatory processes, which could accumulatively modulate chronic disease risk. So far, no comprehensive, integrative profiling has been performed to investigate the effects of longer-term ...
Erk, M.J., van +4 more
core +2 more sources
Gene Expression Profiling of Gastric Cancer [PDF]
Journal of Proteomics & Bioinformatics, 2011 Gastric cancer is the second leading cause of cancer death worldwide, both in men and women. A genomewide gene expression analysis was carried out to identify differentially expressed genes in gastric adenocarcinoma tissues as compared to adjacent normal tissues.
Marimuthu, A.N. +23 more
openaire +3 more sources
The Journal of Reproduction and DevelopmentThis study aimed to develop a method to evaluate the quality of bovine in vitro fertilized (IVF) embryos based on gene expression profiling via whole-transcriptome amplification.
Takashi FUJII +4 more
doaj +1 more source
Improvement of experimental testing and network training conditions with genome-wide microarrays for more accurate predictions of drug gene targets [PDF]
, 2014 BACKGROUND: Genome-wide microarrays have been useful for predicting chemical-genetic interactions at the gene level. However, interpreting genome-wide microarray results can be overwhelming due to the vast output of gene expression data combined with off-
Christadore, Lisa M. +3 more
core +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Potential Roles of miRNA-1245a Regulatory Networks in Sarcopenia
International Journal of General Medicine, 2021 Li An,1 Yao Wang2 1Department of Geriatrics, Zhongda Hospital Southeast University,, Nanjing City, People’s Republic of China; 2Department of Endocrine, Zhongda Hospital Southeast University, Nanjing City, People’s Republic of ChinaCorrespondence: Yao ...
An L, Wang Y
doaj
eLife, 2016 Mammalian lifespan differs by >100 fold, but the mechanisms associated with such longevity differences are not understood. Here, we conducted a study on primary skin fibroblasts isolated from 16 species of mammals and maintained under identical cell ...
Siming Ma +12 more
doaj +1 more source
Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling. [PDF]
, 2010 Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We used integrative molecular profiling to discover and characterize molecular subtypes of LMS.
Beck, A +16 more
core
In vitro identification and in silico utilization of interspecies sequence similarities using GeneChip(® )technology [PDF]
, 2005 BACKGROUND: Genomic approaches in large animal models (canine, ovine etc) are challenging due to insufficient genomic information for these species and the lack of availability of corresponding microarray platforms. To address this problem, we speculated
Garcia, Joe GN +5 more
core +3 more sources