Results 71 to 80 of about 798,938 (348)
Gene expression profiling of the inner ear [PDF]
Journal of Anatomy, 2015 AbstractThe identification of transcriptional differences has served as an important starting point in understanding the molecular mechanisms behind biological processes and systems. The developmental biology of the inner ear, the biology of hearing and of course the pathology of deafness are all processes that warrant a molecular description if we are
Schimmang, Thomas, Maconochie, Mark
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The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
BMC Genomics, 2009 Background Serial analysis of gene expression (LongSAGE) was applied for gene expression profiling in seeds of oilseed rape (Brassica napus ssp. napus).
Friedt Wolfgang +3 more
doaj +1 more source
Gene expression profile of sprinter’s muscle
The FASEB Journal, 2007 We have characterized the global gene expression profile in left vastus lateralis muscles of sprinters and sedentary men. The gene expression profile was analyzed by using a serial analysis of gene expression (SAGE) method. The abundantly expressed transcripts in the sprinter’s muscle were mainly involved in contraction and energy metabolism whereas ...
M, Yoshioka +4 more
openaire +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Gene expression profiling in multiple sclerosis brain
Neurobiology of Disease, 2012 Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system and the leading cause of non-traumatic neurological disability in young adults in the United States and Europe.
Ranjan Dutta, Bruce D. Trapp
doaj +1 more source
One-two punch mechanism of gene repression: a fresh perspective on gene regulation. [PDF]
, 2017 Cellular differentiation depends on temporally controlled waves of gene activation and inactivation that ultimately transform one cell type into another.
Tresenrider, Amy, Ünal, Elçin
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Gene expression profiling of cutaneous wound healing
Journal of Translational Medicine, 2007 Background Although the sequence of events leading to wound repair has been described at the cellular and, to a limited extent, at the protein level this process has yet to be fully elucidated.
Wang Ena +9 more
doaj +1 more source
JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma. [PDF]
, 2016 A prominent mechanism of acquired resistance to BRAF inhibitors in BRAF (V600) -mutant melanoma is associated with the upregulation of receptor tyrosine kinases.
Atefi, Mohammad +16 more
core +3 more sources