Results 71 to 80 of about 208,088 (288)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

MGEnrichment: A web application for microglia gene list enrichment analysis.

PLoS Computational Biology, 2021
Gene expression analysis is becoming increasingly utilized in neuro-immunology research, and there is a growing need for non-programming scientists to be able to analyze their own genomic data.
Justin Jao, Annie Vogel Ciernia
doaj   +1 more source

Modeling association between DNA copy number and gene expression with constrained piecewise linear regression splines [PDF]

, 2013
DNA copy number and mRNA expression are widely used data types in cancer studies, which combined provide more insight than separately. Whereas in existing literature the form of the relationship between these two types of markers is fixed a priori, in ...
Leday, Gwenaël G. R., van de Wiel, Mark A., van der Vaart, Aad W., van Wieringen, Wessel N.   +3 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Image Super-Resolution Based on CNN Using Multilabel Gene Expression Programming

Applied Sciences, 2020
Current mainstream super-resolution algorithms based on deep learning use a deep convolution neural network (CNN) framework to realize end-to-end learning from low-resolution (LR) image to high-resolution (HR) images, and have achieved good image ...
Jiali Tang, Chenrong Huang, Jian Liu, Hongjin Zhu   +3 more
doaj   +1 more source

Optimizing Neural Architecture Search using Limited GPU Time in a Dynamic Search Space: A Gene Expression Programming Approach

, 2020
Efficient identification of people and objects, segmentation of regions of interest and extraction of relevant data in images, texts, audios and videos are evolving considerably in these past years, which deep learning methods, combined with recent ...
Alves, Jeovane Honorio, de Oliveira, Lucas Ferrari   +1 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Incremental Gene Expression Programming Classifier with Metagenes and Data Reduction

Complexity, 2018
The paper proposes an incremental Gene Expression Programming classifier. Its main features include using two-level ensemble consisting of base classifiers in form of genes and the upper-level classifier in the form of metagene.
Joanna Jedrzejowicz, Piotr Jedrzejowicz
doaj   +1 more source

Gene expression program analysis of cancer-testis genes

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To identify the gene expression program (GEP) of cancer-testis genes (CTGs) during spermatogenesis based on single-cell transcriptome data from the testis and investigate their association with the prognosis of cancer patients.Methods·Expression profiles of normal and tumor tissues were obtained from the GTEx and TCGA databases to screen CTGs.
HOU Zongliang, YANG Qin, LI Shaobai, LEI Ming   +3 more
openaire   +1 more source