Results 1 to 10 of about 14 (14)

Gene regulation and genetic susceptibility to neoplastic transformation: AP-1 and p80 expression in JB6 cells. [PDF]

Environmental Health Perspectives, 1991
The mouse epidermal JB6 cell system consists of clonal genetic variants that are sensitive (P+) or resistant (P-) to the promotion of neoplastic transformation by phorbol esters and other tumor-promoting agents. P+ cells display AP-1-dependent phorbol-ester-inducible transactivation of gene expression, whereas P- cells have a defect in transactivation.
Elia T. Ben-Ari, Stephanie L. Simek, Lori R. Bernstein, Nancy H. Colburn   +3 more
openaire   +3 more sources

Id1 Gene Expression Is Up-Regulated in Hyperplastic and Neoplastic Thyroid Tissue and Regulates Growth and Differentiation in Thyroid Cancer Cells [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2004
The Id (inhibitor of DNA binding) proteins are a family of helix-loop-helix (HLH) proteins (Id1, Id2, Id3, and Id4) that lack the basic domain necessary for DNA binding. The Id1 protein enhances cell proliferation and inhibits cellular differentiation in a variety of cell types.
Richard Miner, Orlo H. Clark, Quan-Yang Duh, Electron Kebebew, Patrick A. Treseler, David G. Ginzinger, Miao Peng   +6 more
openaire   +3 more sources

Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance [PDF]

Human Pathology, 2011
Endometrial carcinoma often arises from normal endometrial glandular cells via a precursor, atypical endometrial hyperplasia. However, the genetic changes involved in this carcinogenetic process are not fully understood. Differentially expressed genes were selected from glandular cells of normal proliferative-phase endometria, atypical endometrial ...
Norihiko Kikuchi, Tanri Shiozawa, Hiroyasu Kashima, Tsutomu Miyamoto, Naohiko Seki, Ikuo Konishi, Akihisa Suzuki   +6 more
openaire   +3 more sources

Chromosomal proteins and the regulation of gene expression in normal and neoplastic cells

Leukemia Research, 1977
Leukemia Research 1 (1977) 351-384.
J. Hillis Miller Health Center, University of Florida, Gainesville, FL 32610, U.S.A. ( host institution ), Stein, Gary S., Stein, Janet L., Thomson, Judith A.   +3 more
openaire   +3 more sources

Insoluble Ni compound-induced gene amplification/gene silencing causes over-expression of microtubules/microfilaments, cell shape changes, and de-regulation of global gene expression/Ca+2 gradients, inducing morphological/ neoplastic transformation of 10T1/2 mouse embryo cells

BMC Proceedings, 2010
Inhalation of Ni-containing sulfidic ore dusts and smoking cigarettes in Ni refineries causes human respiratory cancer. Inhalation of Ni3S2 or green NiO induces respiratory cancer in rats. Ni3S2 and green NiO were phagocytosed into and induced morphological/A. I./neoplastic transformation in 10T1/2 mouse embryo cells.
Jim K Lin, Aruni DeSilva, Jimmy Zheng, Joseph R. Landolph, Duy Mai   +4 more
openaire   +2 more sources

Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance

Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance
Endometrial carcinoma often arises from normal endometrial glandular cells via a precursor, atypical endometrial hyperplasia. However, the genetic changes involved in this carcinogenetic process are not fully understood. Differentially expressed genes were selected from glandular cells of normal proliferative-phase endometria, atypical endometrial ...
openaire  

Global Expression Changes of Constitutive and Hormonally Regulated Genes during Endometrial Neoplastic Transformation

Gynecologic Oncology, 2001
Endometrioid endometrial carcinoma is caused by a combination of mutational events and hormonal factors. We used large-scale messenger RNA expression analysis to discover genes that distinguish neoplastic transformation and examine the patterns of tumor expression of those genes which are normally regulated during the menstrual cycle.Expression of ...
Robert Gray, Lee-Jen Wei, George L. Mutter, Gregory A. Kust, Jeffrey T. Fitzgerald, Marsha A. Wilcox, Steven R. Gullans, Robert Gentleman, Donna Neuberg, Jan P.A. Baak   +9 more
openaire   +3 more sources

Epidermal growth factor differentially regulates low density lipoprotein receptor–related protein gene expression in neoplastic and fetal human astrocytes

Glia, 1999
Low density lipoprotein receptor-related protein (LRP) is a multifunctional endocytotic receptor that may modify the biological activity of reactive astrocytes in neuroplasticity and neurodegeneration and of malignant astrocytes in brain invasion. In this study, the regulation of LRP by epidermal growth factor receptor (EGFR) ligands in both cultured ...
Steven L. Gonias, Scott R. VandenBerg, Morry D. Brown, Isa M. Hussaini, Joan E. Carpenter, Larry R. Karns, Gerald T. Redpath   +6 more
openaire   +3 more sources

Hormonal Regulation of Casein Gene Expression in Normal and Neoplastic Cells in Murine Mammary Glands

1982
Contemporary advances of knowledge and technology in the areas of cellular and molecular biology have revealed that selective gene expression plays a definitive role in the regulation of cellular differentiation. In conventional terms, selective gene expression denotes a regulated transcription of different structural genes producing the respective ...
Nozer M. Mehta, Ranjan Ganguly, Nivedita Ganguly, Mihir R. Banerjee   +3 more
openaire   +2 more sources

Growth Regulation and Carcinogenesis

2018
The concept has now gained wide acceptance that carcinogenesis is a multistep process. 1-J After the two operationally defined stages termed “initiation” and “promotion”, more steps seem required before full-fledged malignancy arises, corresponding to transplantable tumors.
Denis English, Lowell Inhorn, Boswell Hs, H. Guenter Derigs, Maureen A. Harrington, Theresa S. Nahreini, Debra Klingberg, Burgess Gs, Theodore G. Gabig   +8 more
openaire   +7 more sources