Results 11 to 20 of about 638,559 (231)

Gene regulation and genetic susceptibility to neoplastic transformation: AP-1 and p80 expression in JB6 cells. [PDF]

Environmental Health Perspectives, 1991
The mouse epidermal JB6 cell system consists of clonal genetic variants that are sensitive (P+) or resistant (P-) to the promotion of neoplastic transformation by phorbol esters and other tumor-promoting agents. P+ cells display AP-1-dependent phorbol-ester-inducible transactivation of gene expression, whereas P- cells have a defect in transactivation.
L R, Bernstein, E T, Ben-Ari, S L, Simek, N H, Colburn   +3 more
openaire   +2 more sources

Id1 Gene Expression Is Up-Regulated in Hyperplastic and Neoplastic Thyroid Tissue and Regulates Growth and Differentiation in Thyroid Cancer Cells [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2004
The Id (inhibitor of DNA binding) proteins are a family of helix-loop-helix (HLH) proteins (Id1, Id2, Id3, and Id4) that lack the basic domain necessary for DNA binding. The Id1 protein enhances cell proliferation and inhibits cellular differentiation in a variety of cell types.
Electron, Kebebew, Miao, Peng, Patrick A, Treseler, Orlo H, Clark, Quan-Yang, Duh, David, Ginzinger, Richard, Miner   +6 more
openaire   +2 more sources

Laser-captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria and its functional relevance [PDF]

Human Pathology, 2011
Endometrial carcinoma often arises from normal endometrial glandular cells via a precursor, atypical endometrial hyperplasia. However, the genetic changes involved in this carcinogenetic process are not fully understood. Differentially expressed genes were selected from glandular cells of normal proliferative-phase endometria, atypical endometrial ...
Tsutomu, Miyamoto, Hiroyasu, Kashima, Akihisa, Suzuki, Norihiko, Kikuchi, Ikuo, Konishi, Naohiko, Seki, Tanri, Shiozawa   +6 more
openaire   +2 more sources

Chromosomal proteins and the regulation of gene expression in normal and neoplastic cells

Leukemia Research, 1977
Leukemia Research 1 (1977) 351-384.
J. Hillis Miller Health Center, University of Florida, Gainesville, FL 32610, U.S.A. ( host institution ), Stein, Gary S., Stein, Janet L., Thomson, Judith A.   +3 more
openaire   +2 more sources

p53: From Fundamental Biology to Clinical Applications in Cancer

Biology, 2022
p53 tumour suppressor gene is our major barrier against neoplastic transformation. It is involved in many cellular functions, including cell cycle arrest, senescence, DNA repair, apoptosis, autophagy, cell metabolism, ferroptosis, immune system ...
Maurizio Capuozzo, Mariachiara Santorsola, Marco Bocchetti, Francesco Perri, Marco Cascella, Vincenza Granata, Venere Celotto, Oreste Gualillo, Alessia Maria Cossu, Guglielmo Nasti, Michele Caraglia, Alessandro Ottaiano   +11 more
doaj   +1 more source

Transcriptomic effects of di-(2-ethylhexyl)-phthalate in Syrian hamster embryo cells: an important role of early cytoskeleton disturbances in carcinogenesis?

BMC Genomics, 2011
Background Di-(2-ethylhexyl)-phthalate (DEHP) is a commonly used plasticizer in polyvinylchloride (PVC) formulations and a potentially non-genotoxic carcinogen.
Atienzar Franck, Poupin Pascal, Landkocz Yann, Vasseur Paule   +3 more
doaj   +1 more source

Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer

International Journal of Cell Biology, 2013
Alternative splicing (AS) is one of the key processes involved in the regulation of gene expression in eukaryotic cells. AS catalyzes the removal of intronic sequences and the joining of selected exons, thus ensuring the correct processing of the primary
Chiara Naro, Claudio Sette
doaj   +1 more source

hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer

Molecular Cancer, 2005
Background The genetic and molecular mechanisms responsible for and associated with the development and progression of prostate malignancy are largely unidentified.
Kajdacsy-Balla André, Singh Keshav K, Desouki Mohamed M, Milon B, Feng Pei, Franklin Renty B, Bagasra Omar, Costello Leslie C   +7 more
doaj   +1 more source

The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival

Analytical Cellular Pathology, 2010
Background: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of ...
Anna G. Antonacopoulou, Konstantina Floratou, Vasiliki Bravou, Anastasia Kottorou, Fotinos-Ioannis Dimitrakopoulos, Stella Marousi, Michalis Stavropoulos, Agelos K. Koutras, Chrisoula D. Scopa, Haralabos P. Kalofonos   +9 more
doaj   +1 more source

"Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells"

Cancer Cell International, 2006
Background p27(Kip1) is a cyclin-dependent kinase inhibitor. When up-regulated, p27 inhibits G1-to-S phase transition of the cell cycle. This report addresses the question of whether various nutritional and chemopreventive anti-cancer agents up-regulate ...
Eto Isao
doaj   +1 more source