Regulation of Normal and Neoplastic Proliferation and Metabolism by the Extended Myc Network
Cells, 2022 The Myc Network, comprising a small assemblage of bHLH-ZIP transcription factors, regulates many hundreds to thousands of genes involved in proliferation, energy metabolism, translation and other activities. A structurally and functionally related set of
Edward V. Prochownik
doaj +1 more source
Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature [PDF]
, 2017 The concept that solid tumors are maintained by a productive interplay between neoplastic and non-neoplastic elements has gained traction with the demonstration that stromal fibroblasts and immune system cells dictate cancer development and progression ...
Bush, Erin C +6 more
core +2 more sources
Long Non-Coding RNAs in the Cell Fate Determination of Neoplastic Thymic Epithelial Cells
Frontiers in Immunology, 2022 Thymic Epithelial Tumors (TETs) arise from epithelial cells of the thymus and are very rare neoplasms comprising Thymoma, Thymic carcinoma, and Thymic Neuroendocrine tumors that still require in-depth molecular characterization.
Alessia Iaiza +14 more
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Frontiers in Endocrinology, 2023 DICER1 is a highly conserved RNase III endoribonuclease essential for the biogenesis of single-stranded mature microRNAs (miRNAs) from stem-loop precursor miRNAs.
Julio C. Ricarte-Filho +20 more
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The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling [PDF]
, 2018 Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease
Antonelli, Manila +19 more
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p53: From Fundamental Biology to Clinical Applications in Cancer
Biology, 2022 p53 tumour suppressor gene is our major barrier against neoplastic transformation. It is involved in many cellular functions, including cell cycle arrest, senescence, DNA repair, apoptosis, autophagy, cell metabolism, ferroptosis, immune system ...
Maurizio Capuozzo +11 more
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PARP-1 regulates DNA repair factor availability. [PDF]
, 2018 PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP-1 enzymatic
Birbe, Ruth +31 more
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Chromosomal proteins and the regulation of gene expression in normal and neoplastic cells
Leukemia Research, 1977 Leukemia Research 1 (1977) 351-384.
J. Hillis Miller Health Center, University of Florida, Gainesville, FL 32610, U.S.A. ( host institution ) +3 more
openaire +2 more sources
Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis [PDF]
, 2016 Metabolic changes are associated with cancer, but whether they are just bystander effects of deregulated oncogenic signaling pathways or characterize early phases of tumorigenesis remains unclear.
Angioni, Maria Maddalena +16 more
core +3 more sources
BMC Genomics, 2011 Background Di-(2-ethylhexyl)-phthalate (DEHP) is a commonly used plasticizer in polyvinylchloride (PVC) formulations and a potentially non-genotoxic carcinogen.
Atienzar Franck +3 more
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