Results 11 to 20 of about 609,943 (233)

Long Non-Coding RNAs in the Cell Fate Determination of Neoplastic Thymic Epithelial Cells

Frontiers in Immunology, 2022
Thymic Epithelial Tumors (TETs) arise from epithelial cells of the thymus and are very rare neoplasms comprising Thymoma, Thymic carcinoma, and Thymic Neuroendocrine tumors that still require in-depth molecular characterization.
Alessia Iaiza, Claudia Tito, Federica Ganci, Andrea Sacconi, Enzo Gallo, Silvia Masciarelli, Silvia Masciarelli, Giulia Fontemaggi, Alessandro Fatica, Enrico Melis, Vincenzo Petrozza, Federico Venuta, Mirella Marino, Giovanni Blandino, Francesco Fazi   +14 more
doaj   +1 more source

DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer

Frontiers in Endocrinology, 2023
DICER1 is a highly conserved RNase III endoribonuclease essential for the biogenesis of single-stranded mature microRNAs (miRNAs) from stem-loop precursor miRNAs.
Julio C. Ricarte-Filho, Victoria Casado-Medrano, Erin Reichenberger, Zachary Spangler, Michele Scheerer, Amber Isaza, Julia Baran, Tasleema Patel, Suzanne P. MacFarland, Suzanne P. MacFarland, Garrett M. Brodeur, Garrett M. Brodeur, Garrett M. Brodeur, Douglas R. Stewart, Zubair Baloch, Andrew J. Bauer, Andrew J. Bauer, Jonathan D. Wasserman, Aime T. Franco, Aime T. Franco, Aime T. Franco   +20 more
doaj   +1 more source

Chromosomal proteins and the regulation of gene expression in normal and neoplastic cells

Leukemia Research, 1977
Leukemia Research 1 (1977) 351-384.
J. Hillis Miller Health Center, University of Florida, Gainesville, FL 32610, U.S.A. ( host institution ), Stein, Gary S., Stein, Janet L., Thomson, Judith A.   +3 more
openaire   +2 more sources

p53: From Fundamental Biology to Clinical Applications in Cancer

Biology, 2022
p53 tumour suppressor gene is our major barrier against neoplastic transformation. It is involved in many cellular functions, including cell cycle arrest, senescence, DNA repair, apoptosis, autophagy, cell metabolism, ferroptosis, immune system ...
Maurizio Capuozzo, Mariachiara Santorsola, Marco Bocchetti, Francesco Perri, Marco Cascella, Vincenza Granata, Venere Celotto, Oreste Gualillo, Alessia Maria Cossu, Guglielmo Nasti, Michele Caraglia, Alessandro Ottaiano   +11 more
doaj   +1 more source

Transcriptomic effects of di-(2-ethylhexyl)-phthalate in Syrian hamster embryo cells: an important role of early cytoskeleton disturbances in carcinogenesis?

BMC Genomics, 2011
Background Di-(2-ethylhexyl)-phthalate (DEHP) is a commonly used plasticizer in polyvinylchloride (PVC) formulations and a potentially non-genotoxic carcinogen.
Atienzar Franck, Poupin Pascal, Landkocz Yann, Vasseur Paule   +3 more
doaj   +1 more source

Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer

International Journal of Cell Biology, 2013
Alternative splicing (AS) is one of the key processes involved in the regulation of gene expression in eukaryotic cells. AS catalyzes the removal of intronic sequences and the joining of selected exons, thus ensuring the correct processing of the primary
Chiara Naro, Claudio Sette
doaj   +1 more source

hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer

Molecular Cancer, 2005
Background The genetic and molecular mechanisms responsible for and associated with the development and progression of prostate malignancy are largely unidentified.
Kajdacsy-Balla André, Singh Keshav K, Desouki Mohamed M, Milon B, Feng Pei, Franklin Renty B, Bagasra Omar, Costello Leslie C   +7 more
doaj   +1 more source

Circular RNA as An Epigenetic Regulator in Chronic Liver Diseases

Cells, 2021
Circular RNA (circRNA) is a type of non-coding RNA characterized by a covalently closed continuous loop. CircRNA is generated by pre-mRNA through back-splicing and is probably cleared up by extracellular vesicles.
Xianhui Zeng, Xianglei Yuan, Qiuyu Cai, Chengwei Tang, Jinhang Gao   +4 more
doaj   +1 more source

"Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells"

Cancer Cell International, 2006
Background p27(Kip1) is a cyclin-dependent kinase inhibitor. When up-regulated, p27 inhibits G1-to-S phase transition of the cell cycle. This report addresses the question of whether various nutritional and chemopreventive anti-cancer agents up-regulate ...
Eto Isao
doaj   +1 more source

The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival

Analytical Cellular Pathology, 2010
Background: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of ...
Anna G. Antonacopoulou, Konstantina Floratou, Vasiliki Bravou, Anastasia Kottorou, Fotinos-Ioannis Dimitrakopoulos, Stella Marousi, Michalis Stavropoulos, Agelos K. Koutras, Chrisoula D. Scopa, Haralabos P. Kalofonos   +9 more
doaj   +1 more source