Results 31 to 40 of about 668,253 (275)

Emerging role of the pentose phosphate pathway in hepatocellular carcinoma [PDF]

, 2017
In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined.
Columbano, Amedeo, Kowalik, MARTA ANNA, Perra, Andrea   +2 more
core   +2 more sources

Comparative study of gene expression by cDNA microarray in human colorectal cancer tissues and normal mucosa [PDF]

, 2006
The causative molecular pathways underlying the pathogenesis of colorectal cancer (CRC) need to be better characterized. The purpose of our study was to better understand the genetic mechanism of oncogenesis for human colorectal cancer and to identify ...
Bianchini, Michele, Carinci, Paolo, De Sanctis, Paola, Levy, Estrella Mariel, Macagno, Carlo, Mordoh, Jose, Pinski, Victor, Valvassori, Luisa, Zucchini, Cinzia   +8 more
core   +1 more source

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
core   +2 more sources

Genomics and proteomics approaches to the study of cancer-stroma interactions

BMC Medical Genomics, 2010
Background The development and progression of cancer depend on its genetic characteristics as well as on the interactions with its microenvironment.
Fukuyama Erica E, Teixeira Rodrigo AP, Souza Caique F, Henrique Tiago, Cunha Bianca R, Carmona-Raphe Juliana, Maniglia José V, Polachini Giovana M, Vidotto Alessandra, Peitl Paulo, Rodrigues-Lisoni Flávia C, Michaluart Pedro, de Carvalho Marcos B, Oliani Sonia M, Tajara Eloiza H   +14 more
doaj   +1 more source

Analysis of High-Risk Neuroblastoma Transcriptome Reveals Gene Co-Expression Signatures and Functional Features

Biology, 2023
Neuroblastoma represents a neoplastic expansion of neural crest cells in the developing sympathetic nervous system and is childhood’s most common extracranial solid tumor.
Mónica Leticia Martínez-Pacheco, Enrique Hernández-Lemus, Carmen Mejía   +2 more
doaj   +1 more source

Analysis of apoptosis related genes in nurses exposed to anti-neoplastic drugs

BMC Pharmacology and Toxicology, 2019
Background Anti-neoplastic agents are widely used in the treatment of cancer and some non-neoplastic diseases. These drugs have been proved to be carcinogens, teratogens, and mutagens.
Maral Ramazani, Razieh Pourahmad Jaktaji, Farshad H. Shirazi, Maria Tavakoli-Ardakani, Ahmad Salimi, Jalal Pourahmad   +5 more
doaj   +1 more source

PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation

Biology, 2013
PRDM (PRDI-BF1 and RIZ homology domain containing) protein family members are characterized by the presence of a PR domain and a variable number of Zn-finger repeats.
Bruno Moncharmont, Ciro Abbondanza, Caterina De Rosa, Erika Di Zazzo   +3 more
doaj   +1 more source

NSD1 Mutations in Sotos Syndrome Induce Differential Expression of Long Noncoding RNAs, miR646 and Genes Controlling the G2/M Checkpoint

Life, 2022
An increasing amount of evidence indicates the critical role of the NSD1 gene in Sotos syndrome (SoS), a rare genetic disease, and in tumors. Molecular mechanisms affected by NSD1 mutations are largely uncharacterized.
Giuseppina Conteduca, Davide Cangelosi, Simona Coco, Michela Malacarne, Chiara Baldo, Alessia Arado, Rute Pinto, Barbara Testa, Domenico A. Coviello   +8 more
doaj   +1 more source

Neurofibromin knockdown in glioma cell lines is associated with changes in cytokine and chemokine secretion in vitro. [PDF]

, 2018
The neurofibromin-1 tumor suppressor gene (NF1) is altered in approximately 20% of sporadic glioblastoma (GBM) cases. NF1 deficient GBM frequently shows a mesenchymal gene expression signature, suggesting a relationship between NF1 status and the tumor ...
Mukherjee, Joydeep, Pieper, Russell O, Wood, Matthew D   +2 more
core   +3 more sources

Aberrant expression of NPPB through YAP1 and TAZ activation in mesothelioma with Hippo pathway gene alterations

Cancer Medicine, 2023
Background Mesothelioma is a neoplastic disease associated with asbestos exposure. It is highly malignant and has a poor prognosis; thus, early detection is desirable. Recent whole‐genome analysis has revealed that mesothelioma is characterized by a high
Tatsuhiro Sato, Ken Akao, Ayuko Sato, Tohru Tsujimura, Satomi Mukai, Yoshitaka Sekido   +5 more
doaj   +1 more source