Results 31 to 40 of about 7,007,953 (262)

Aberrant expression of NPPB through YAP1 and TAZ activation in mesothelioma with Hippo pathway gene alterations

Cancer Medicine, 2023
Background Mesothelioma is a neoplastic disease associated with asbestos exposure. It is highly malignant and has a poor prognosis; thus, early detection is desirable. Recent whole‐genome analysis has revealed that mesothelioma is characterized by a high
Tatsuhiro Sato, Ken Akao, Ayuko Sato, Tohru Tsujimura, Satomi Mukai, Yoshitaka Sekido   +5 more
doaj   +1 more source

NSD1 Mutations in Sotos Syndrome Induce Differential Expression of Long Noncoding RNAs, miR646 and Genes Controlling the G2/M Checkpoint

Life, 2022
An increasing amount of evidence indicates the critical role of the NSD1 gene in Sotos syndrome (SoS), a rare genetic disease, and in tumors. Molecular mechanisms affected by NSD1 mutations are largely uncharacterized.
Giuseppina Conteduca, Davide Cangelosi, Simona Coco, Michela Malacarne, Chiara Baldo, Alessia Arado, Rute Pinto, Barbara Testa, Domenico A. Coviello   +8 more
doaj   +1 more source

Walleye Dermal Sarcoma Virus: Molecular Biology and Oncogenesis

Viruses, 2010
Retroviruses have been detected in most vertebrate species and are etiologic agents of a variety of neoplastic diseases. The study of retroviruses has been instrumental in uncovering the molecular mechanisms responsible for oncogenesis. Retroviruses have
Sandra L. Quackenbush, Joel Rovnak
doaj   +1 more source

The alteration of lipid metabolism in Burkitt lymphoma identifies a novel marker: adipophilin. [PDF]

PLoS ONE, 2012
Recent evidence suggests that lipid pathway is altered in many human tumours. In Burkitt lymphoma this is reflected by the presence of lipid droplets which are visible in the cytoplasm of neoplastic cells in cytological preparations.
Maria R Ambrosio, Pier P Piccaluga, Maurilio Ponzoni, Bruno J Rocca, Valeria Malagnino, Monica Onorati, Giulia De Falco, Valeria Calbi, Martin Ogwang, Kikkeri N Naresh, Stefano A Pileri, Claudio Doglioni, Lorenzo Leoncini, Stefano Lazzi   +13 more
doaj   +1 more source

Transcription Profile and Pathway Analysis of the Endocannabinoid Receptor Inverse Agonist AM630 in the Core and Infiltrative Boundary of Human Glioblastoma Cells

Molecules, 2022
Background: We have previously reported that the endocannabinoid receptor inverse agonist AM630 is a potent inhibitor of isocitrade dehydrogenase-1 wild-type glioblastoma (GBM) core tumour cell proliferation.
Gareth Williams, David Chambers, Ruman Rahman, Francisco Molina-Holgado   +3 more
doaj   +1 more source

Differential timing of gene expression regulation between leptocephali of the two Anguilla eel species in the Sargasso Sea [PDF]

, 2011
The unique life-history characteristics of North Atlantic catadromous eels have long intrigued evolutionary biologists, especially with respect to mechanisms that could explain their persistence as two ecologically very similar but reproductively and ...
Maes, Gregory E., Als, Thomas Damm, Als, Thomas D., Martin Castonguay, Michael M. Hansen, Jérôme St-Cyr, Bernatchez, Louis, Louis Bernatchez, Thomas D. Als, Eric Normandeau, St-Cyr, Jerome, Als, Thomas, Cramb, Gordon, Saint-Cyr, Jérôme, Gordon Cramb, Maes, Gregory, Kalujnaia, S., Hansen, Michael M., Normandeau, Eric, Svetlana Kalujnaia, Hansen, Michael Møller, Kalujnaia, Svetlana, Hansen, Michael, Gregory E. Maes, Castonguay, Martin   +24 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A scoring model for the expression of genes related to programmed cell death predicts immunotherapy response and prognosis in lung adenocarcinoma

Discover Oncology
Background Lung adenocarcinoma (LUAD) continues to be the leading cause of cancer death worldwide, driven by environmental factors like smoking and genetic predispositions. LUAD has a high mortality rate, and new biomarkers are urgently needed to improve
Runan Jia, Xiaolong Liang, Jianfei Tu, Hongyuan Yang   +3 more
doaj   +1 more source

EpiMethEx: a tool for large-scale integrated analysis in methylation hotspots linked to genetic regulation

BMC Bioinformatics, 2019
Background DNA methylation is an epigenetic mechanism of genomic regulation involved in the maintenance of homeostatic balance. Dysregulation of DNA methylation status is one of the driver alterations occurring in neoplastic transformation and cancer ...
Saverio Candido, Giuseppe Alessandro Parasiliti Palumbo, Marzio Pennisi, Giulia Russo, Giuseppe Sgroi, Valentina Di Salvatore, Massimo Libra, Francesco Pappalardo   +7 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source