Results 1 to 10 of about 638,559 (231)

Functions and mechanisms of miR-650 in human diseases [PDF]

Frontiers in Molecular Biosciences
MicroRNAs (miRNAs) are endogenous, single-stranded, small non-coding RNAs that play central roles in gene expression regulation. Among them, miR-650 has received increasing attention over the past decade because it regulates cell proliferation ...
Qingmiao Shi, Chengran Gao, Chen Xue
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Promoter Demethylation Upregulates STEAP1 Gene Expression in Human Prostate Cancer: In Vitro and In Silico Analysis

Life, 2021
The Six Transmembrane Epithelial Antigen of the Prostate (STEAP1) is an oncogene overexpressed in several human tumors, particularly in prostate cancer (PCa). However, the mechanisms involved in its overexpression remain unknown.
Sandra M. Rocha, Inês Sousa, Inês M. Gomes, Patrícia Arinto, Pedro Costa-Pinheiro, Eduarda Coutinho, Cecília R. Santos, Carmen Jerónimo, Manuel C. Lemos, Luís A. Passarinha, Sílvia Socorro, Cláudio J. Maia   +11 more
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p53 increases intra-cellular calcium release by transcriptional regulation of calcium channel TRPC6 in GaQ3-treated cancer cells. [PDF]

PLoS ONE, 2013
p53 and calcium signaling are inter-dependent and are known to show both synergistic and antagonistic effects on each other in the cellular environment.
Esha Madan, Rajan Gogna, Bernhard Keppler, Uttam Pati   +3 more
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Assessment of the TGFB1 gene expression and methylation status of the promoter region in patients with colorectal cancer

Scientific Reports, 2022
The aim of this study was to evaluate the expression of the TGFB1 gene encoding the TGF-β1 cytokine in 64 patients, and then to compare it with clinico-pathological features.
Damian Wodziński, Agnieszka Wosiak, Jacek Pietrzak, Rafał Świechowski, Radzisław Kordek, Ewa Balcerczak   +5 more
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Relevance of miR-223 as Potential Diagnostic and Prognostic Markers in Cancer

Biology, 2022
In 1993, the discovery of microRNAs in Caenorhabditis elegans (C. elegans) altered the paradigmatic view of RNA biology and post-transcriptional gene regulation. Further study revealed the role of microRNAs in disease development and progression.
Faisal Aziz, Abhijit Chakraborty, Imran Khan, Josh Monts   +3 more
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Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers

Open Life Sciences, 2021
This long-term research was designed to evaluate whether superoxide dismutase (SOD) isoenzymes participate in the development of human gastrointestinal neoplasms and the potential influence of the sigma1 receptor (Sig1R) on the regulation of SOD gene ...
Skrzycki Michał
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Decoding meningioma heterogeneity and neoplastic cell—macrophage interaction through single-cell transcriptome profiling across pathological grades

Journal of Translational Medicine, 2023
Background Analyzing meningioma of distinct pathological types at the single-cell level can provide new and valuable insights into the specific biological mechanisms of each cellular subpopulation, as well as their vital interplay within the tumor ...
Hailang Fan, Lairong Song, Jian Fan, Junpeng Ma, Xiaojie Li, Junting Zhang, Jian Hu, Zhen Wu, Dake Zhang, Liang Wang   +9 more
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Long Non-Coding RNAs in the Cell Fate Determination of Neoplastic Thymic Epithelial Cells

Frontiers in Immunology, 2022
Thymic Epithelial Tumors (TETs) arise from epithelial cells of the thymus and are very rare neoplasms comprising Thymoma, Thymic carcinoma, and Thymic Neuroendocrine tumors that still require in-depth molecular characterization.
Alessia Iaiza, Claudia Tito, Federica Ganci, Andrea Sacconi, Enzo Gallo, Silvia Masciarelli, Silvia Masciarelli, Giulia Fontemaggi, Alessandro Fatica, Enrico Melis, Vincenzo Petrozza, Federico Venuta, Mirella Marino, Giovanni Blandino, Francesco Fazi   +14 more
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Regulation of Normal and Neoplastic Proliferation and Metabolism by the Extended Myc Network

Cells, 2022
The Myc Network, comprising a small assemblage of bHLH-ZIP transcription factors, regulates many hundreds to thousands of genes involved in proliferation, energy metabolism, translation and other activities. A structurally and functionally related set of
Edward V. Prochownik
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DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer

Frontiers in Endocrinology, 2023
DICER1 is a highly conserved RNase III endoribonuclease essential for the biogenesis of single-stranded mature microRNAs (miRNAs) from stem-loop precursor miRNAs.
Julio C. Ricarte-Filho, Victoria Casado-Medrano, Erin Reichenberger, Zachary Spangler, Michele Scheerer, Amber Isaza, Julia Baran, Tasleema Patel, Suzanne P. MacFarland, Suzanne P. MacFarland, Garrett M. Brodeur, Garrett M. Brodeur, Garrett M. Brodeur, Douglas R. Stewart, Zubair Baloch, Andrew J. Bauer, Andrew J. Bauer, Jonathan D. Wasserman, Aime T. Franco, Aime T. Franco, Aime T. Franco   +20 more
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