Regulation of Normal and Neoplastic Proliferation and Metabolism by the Extended Myc Network
Cells, 2022 The Myc Network, comprising a small assemblage of bHLH-ZIP transcription factors, regulates many hundreds to thousands of genes involved in proliferation, energy metabolism, translation and other activities. A structurally and functionally related set of
Edward V. Prochownik
doaj +2 more sources
Classification, function, and advances in tsRNA in non-neoplastic diseases
Cell Death and Disease, 2023 tRNA-derived small RNAs (tsRNAs) are non-coding small RNAs produced by specific endonucleases following the processing and splicing of precursor or mature tRNAs upon starvation, oxidative stress, hypoxia, and other adverse conditions.
Liou Zhang, Jie Liu, Yang Hou
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Cancer Cell International, 2022 Resveratrol (3,5,4′-trihydroxy- trans -stilbene) is a natural phenol that is present in the skin of the grape, blueberry, raspberry, mulberry, and peanut.
S. Ghafouri‐Fard +7 more
semanticscholar +1 more source
Long Non-Coding RNAs in the Cell Fate Determination of Neoplastic Thymic Epithelial Cells
Frontiers in Immunology, 2022 Thymic Epithelial Tumors (TETs) arise from epithelial cells of the thymus and are very rare neoplasms comprising Thymoma, Thymic carcinoma, and Thymic Neuroendocrine tumors that still require in-depth molecular characterization.
Alessia Iaiza +14 more
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Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]
, 2016 Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A. +13 more
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Frontiers in Endocrinology, 2023 DICER1 is a highly conserved RNase III endoribonuclease essential for the biogenesis of single-stranded mature microRNAs (miRNAs) from stem-loop precursor miRNAs.
Julio C. Ricarte-Filho +20 more
doaj +1 more source
p53: From Fundamental Biology to Clinical Applications in Cancer
Biology, 2022 p53 tumour suppressor gene is our major barrier against neoplastic transformation. It is involved in many cellular functions, including cell cycle arrest, senescence, DNA repair, apoptosis, autophagy, cell metabolism, ferroptosis, immune system ...
Maurizio Capuozzo +11 more
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Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells [PDF]
, 2015 Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first-line chemotherapeutic approach.
Bielli, P +7 more
core +2 more sources
Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
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Chromosomal proteins and the regulation of gene expression in normal and neoplastic cells
Leukemia Research, 1977 Leukemia Research 1 (1977) 351-384.
J. Hillis Miller Health Center, University of Florida, Gainesville, FL 32610, U.S.A. ( host institution ) +3 more
openaire +2 more sources