Results 241 to 250 of about 8,100,350 (339)

The role of two major nucleoid-associated proteins in Streptomyces, HupA and HupS, in stress survival and gene expression regulation. [PDF]

Microb Cell Fact
Strzałka A, Mikołajczyk J, Kowalska K, Skurczyński M, Holmes NA, Jakimowicz D.   +5 more
europepmc   +1 more source

Hierarchical Gene Cluster Regulation Across Vertebrate Skins: Developmental Control of Keratin Gene Expression

Wen-Chien Jea, Ping Wu, Chih-Kuan Chen, Cheng-Ming Chuong, Ya-Chen Liang   +4 more
openalex   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Stress-Induced Changes in Nucleocytoplasmic Localization of Crucial Factors in Gene Expression Regulation. [PDF]

Int J Mol Sci
Khamit A, Chakraborty P, Zahorán S, Villányi Z, Orvos H, Hermesz E.   +5 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

A Bidirectional Non-Coding RNA Promoter Mediates Long-Range Gene Expression Regulation. [PDF]

Genes (Basel)
Peralta-Alvarez CA, Núñez-Martínez HN, Cerecedo-Castillo ÁJ, Poot-Hernández AC, Tapia-Urzúa G, Garza-Manero S, Guerrero G, Recillas-Targa F.   +7 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Dynamic BMP gene expression regulation in chick RPE during recovery from short term optical defocus and form-deprivation. [PDF]

PLoS One
Zhang Y, Zhu Q, Song W, Chuang GM, Sun D, Cheung K, Chou A, He A, Shoghi E, Wildsoet CF.   +9 more
europepmc   +1 more source

Epigenetic regulation of the TET2 gene in Iraqi patients with acute myeloid leukemia: Expression and methylation analysis

Karar M. Jaleel, Risala H. Allami, Ammar Basim Al-Asadi   +2 more
openalex   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source