Results 11 to 20 of about 1,724,839 (265)
Journal of Lipid Research, 2002 Development of the lipase gene family spans the change in science that witnessed the birth of contemporary techniques of molecular biology. Amino acid sequencing of enzymes gave way to cDNA cloning and gene organization, augmented by in vitro expression ...
Howard Wong, Michael C. Schotz
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Biomolecular Concepts, 2014 MDM2 is an oncoprotein that blocks p53 tumor suppressor-mediated transcriptional transactivation, escorts p53 from the cell nucleus to the cytoplasm, and polyubiquitylates p53.
Mendoza Michael +2 more
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Retinoblastoma family genes [PDF]
Oncogene, 2006 The retinoblastoma gene Rb was the first tumor suppressor gene cloned, and it is well known as a negative regulator of the cell cycle through its ability to bind the transcription factor E2F and repress transcription of genes required for S phase. Although over 100 other proteins have been reported to interact with Rb, in most cases these interactions ...
W, Du, J, Pogoriler
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Plants, 2022 Lateral organ boundaries domain (LBD) proteins are plant-specific transcription factors that play important roles in organ development and stress response. However, the function of LBD genes has not been reported in Euphorbiaceae.
Qi Jin +4 more
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Gene Cluster Statistics with Gene Families [PDF]
Molecular Biology and Evolution, 2009 Identifying genomic regions that descended from a common ancestor is important for understanding the function and evolution of genomes. In distantly related genomes, clusters of homologous gene pairs are evidence of candidate homologous regions. Demonstrating the statistical significance of such "gene clusters" is an essential component of comparative ...
Raghupathy, Narayanan, Durand, Dannie
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Life, 2022 Dendrobium catenatum is an important herb and widely cultivated in China. GDSL-Type Esterase/Lipase proteins (GELPs) are widely distributed in plants and play crucial roles in stress responses, plant growth, and development. However, no identification or
Xinqiao Zhan, Yichun Qian, Bizeng Mao
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Coevolution of gene families in prokaryotes [PDF]
Genome Research, 2008 We study gene family coevolution on a tree of life based on a large-scale ancestral gene content reconstruction, which includes gene duplication and deletion events. The insights obtained from this study are threefold: (1) Global properties, such as the distribution of coevolution partners and the formation of disconnected clusters of coevolving ...
Cordero Sanchez, O.X +2 more
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Lipocalin-2 in Fructose-Induced Fatty Liver Disease
Frontiers in Physiology, 2017 The intake of excess dietary fructose most often leads to non-alcoholic fatty liver disease (NAFLD). Fructose is metabolized mainly in the liver and its chronic consumption results in lipogenic gene expression in this organ.
Jessica Lambertz +5 more
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Frontiers in Genetics, 2021 The NAC transcription factor (TF) is one of the most significant TFs in plants and is widely involved in plant growth, development, and responses to biotic and abiotic stresses.
Pengxiang Li +11 more
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Oncogene, 1999 p73 and p63 are two recently discovered p53 homologs. Like p53, these proteins can recognize canonical p53 DNA-binding sites and, when overproduced, can activate p53-responsive target genes and induce apoptosis. Unlike p53, these genes undergo complex alternative splicing which, at least in the case of p63, yields proteins with widely divergent ...
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