Results 11 to 20 of about 7,804,402 (208)
Journal of Lipid Research, 2002 Development of the lipase gene family spans the change in science that witnessed the birth of contemporary techniques of molecular biology. Amino acid sequencing of enzymes gave way to cDNA cloning and gene organization, augmented by in vitro expression ...
Howard Wong, Michael C. Schotz
doaj +3 more sources
Biomolecular Concepts, 2014 MDM2 is an oncoprotein that blocks p53 tumor suppressor-mediated transcriptional transactivation, escorts p53 from the cell nucleus to the cytoplasm, and polyubiquitylates p53.
Mendoza Michael +2 more
doaj +3 more sources
Retinoblastoma family genes [PDF]
Oncogene, 2006 The retinoblastoma gene Rb was the first tumor suppressor gene cloned, and it is well known as a negative regulator of the cell cycle through its ability to bind the transcription factor E2F and repress transcription of genes required for S phase. Although over 100 other proteins have been reported to interact with Rb, in most cases these interactions ...
W, Du, J, Pogoriler
openaire +2 more sources
Characterization of Murine Carcinoembryonic Antigen Gene Family Members [PDF]
, 1992 The carcinoembryonic antigen (CEA) is a human tumor marker whose gene belongs to a family with more than 20 members. This gene family codes for a group of proteins with in vitro cell adhesion properties and for a group of abundantly expressed pregnancy ...
Zimmermann, Wolfgang +4 more
core +2 more sources
Plants, 2022 Lateral organ boundaries domain (LBD) proteins are plant-specific transcription factors that play important roles in organ development and stress response. However, the function of LBD genes has not been reported in Euphorbiaceae.
Qi Jin +4 more
doaj +1 more source
Life, 2022 Dendrobium catenatum is an important herb and widely cultivated in China. GDSL-Type Esterase/Lipase proteins (GELPs) are widely distributed in plants and play crucial roles in stress responses, plant growth, and development. However, no identification or
Xinqiao Zhan, Yichun Qian, Bizeng Mao
doaj +1 more source
Carcinoembryonic Antigen Gene Family [PDF]
, 1991 The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin supergene family and can be divided into two main subgroups based on sequence comparisons.
Zimmermann, Wolfgang +2 more
core +1 more source
Gene Cluster Statistics with Gene Families [PDF]
Molecular Biology and Evolution, 2009 Identifying genomic regions that descended from a common ancestor is important for understanding the function and evolution of genomes. In distantly related genomes, clusters of homologous gene pairs are evidence of candidate homologous regions. Demonstrating the statistical significance of such "gene clusters" is an essential component of comparative ...
Raghupathy, Narayanan, Durand, Dannie
openaire +2 more sources
Coevolution of gene families in prokaryotes [PDF]
Genome Research, 2008 We study gene family coevolution on a tree of life based on a large-scale ancestral gene content reconstruction, which includes gene duplication and deletion events. The insights obtained from this study are threefold: (1) Global properties, such as the distribution of coevolution partners and the formation of disconnected clusters of coevolving ...
Cordero Sanchez, O.X +2 more
openaire +3 more sources
Lipocalin-2 in Fructose-Induced Fatty Liver Disease
Frontiers in Physiology, 2017 The intake of excess dietary fructose most often leads to non-alcoholic fatty liver disease (NAFLD). Fructose is metabolized mainly in the liver and its chronic consumption results in lipogenic gene expression in this organ.
Jessica Lambertz +5 more
doaj +1 more source