Results 341 to 350 of about 11,121,866 (385)

SMARCAfamily of genes

Journal of Clinical Pathology, 2020
TheSMARCAsubgroup of genes belong to the SWI1/SNF1 family that are responsible chromatin remodelling and repair. Inactivating mutations in the mainSMARCAgenesA2andA4lead to loss of expression of their respective proteins within the nucleus and, as such have characterised a set of malignancies that are underpinned by SMARCA-deficiency.The morphology of ...
Runjan Chetty, Stefano Serra
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Gene Structure and Gene Families

2019
Approaches for the discovery of protein-coding genes were described in detail in Chap. 3. These included EST sequencing, RNA-seq, and full genome sequencing. Raw DNA sequences generated by these approaches are assembled into sets that are assumed to come from a single genetic locus. These are often called unigene sets.
David B. Neale, Nicholas C. Wheeler
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Adaptive evolution of genes and gene families

Current Opinion in Genetics & Development, 2003
The huge influx of genomic sequence and new statistical methods is making the discovery of genes subjected to adaptive evolution increasingly common. The use of comparative genomics to identify adaptive evolution is resulting in predictions of functionally important genes and gene regions.
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Gene Families and Evolution [PDF]

, 2003
Gene families refer to two or more genes that come from a common ancestral gene in which the individual members of the gene family may or may not have a similar function. The idea of gene families implicitly invokes a process in which an original gene exists, is duplicated and the resulting gene products evolve.
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β1,3-glycosyltransferase Gene Family and IGnT Gene Family

2009
This section mainly reviews β1,3-glycosyltransferases (β3GT), which transfer donor substrate sugars via a β1,3-linkage, and IGnTs, which transfer donor substrate sugars via a β1,6-linkage (Hennet 2002; Narimatsu 2004; Togayachi 2006). Information such as accession numbers of these β3GTs and IGnTs are shown in Table 1.
Takashi Sato, Hisashi Narimatsu, Akira Togayachi   +2 more
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Evolution of the spermadhesin gene family

Gene, 2005
Spermadhesins belong to a novel family of secretory proteins of the male genital tract. They are major proteins of the seminal plasma and have been found peripherally associated to the sperm surface. So far, they have only been detected in ungulates, specifically in pig, cattle, and horse, respectively.
Tosso Leeb, Bianca Haase, Christian Schlötterer, Heidi Kuiper, Ottmar Distl, Edda Töpfer-Petersen, Mahnaz Ekhlasi Hundrieser   +6 more
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Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.

Physiological Reviews, 2008
The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most tissues, CD38 (and CD157) cleaves NAD(+) and NADP(+), generating cyclic ADP ...
F. Malavasi, S. Deaglio, A. Funaro, E. Ferrero, A. Horenstein, E. Ortolan, T. Vaisitti, Semra Aydin   +7 more
semanticscholar   +1 more source

Ras-like genes and gene families in the mouse

Mammalian Genome, 1991
Four human RAS-like cDNAs and a mouse genomic DNA fragment were used to define novel mouse Ras-like genes and gene families. Inheritance of DNA restriction fragment length variants associated with these genes in recombinant inbred and backcross mice allowed definition of 12 genetic loci, nine of which were mapped, to chromosomes (Chr) 2, 4, 7, 8, 9 ...
George Drivas, Peter D'Eustachio, Hwan-You Chang, Randi Massey, Mark G. Rush   +4 more
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The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.

Physiological Reviews, 2007
For a long time, superoxide generation by an NADPH oxidase was considered as an oddity only found in professional phagocytes. Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5 ...
K. Bedard, K. Krause
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Gene factories, microfunctionalization and the evolution of gene families [PDF]

Trends in Genetics, 2005
Gene duplication has long been considered an important force in genome evolution. In this article, I consider families of tandemly duplicated genes that show 'microfunctionalization' - genes encoding similar proteins with subtly different functions, such as olfactory receptors.
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