Results 51 to 60 of about 3,050,344 (306)

Engineering filamentous potato virus X as a platform nanotechnology for nucleic acid gene delivery

Scientific Reports
Nucleic acid therapeutics and gene delivery platforms have the potential to change the way we treat disease, enabling precision medicine. Advances in biotechnology have allowed for production of virtually any functional protein or peptide in the human ...
Bryan Duoto, Michael Tong, Krister J. Barkovich, Juliane Schuphan, Prashant Mali, Nicole F. Steinmetz   +5 more
doaj   +1 more source

Hsf transcription factor gene family in peanut (Arachis hypogaea L.): genome-wide characterization and expression analysis under drought and salt stresses

Frontiers in Plant Science, 2023
Heat shock transcription factors (Hsfs) play important roles in plant developmental regulations and various stress responses. In present study, 46 Hsf genes in peanut (AhHsf) were identified and analyzed. The 46 AhHsf genes were classed into three groups
Qi Wang, Zhenbiao Zhang, Cun Guo, Xiaobo Zhao, Zhiyuan Li, Yifei Mou, Quanxi Sun, Juan Wang, Cuiling Yuan, Chunjuan Li, Ping Cong, Shihua Shan   +11 more
doaj   +1 more source

Further genetic heterogeneity for autosomal dominant human sutural cataracts [PDF]

, 2003
A unique sutural cataract was observed in a 4-generation German family to be transmitted as an isolated autosomal, dominant trait. Since mutations in the gamma-crystallin encoding CRYG genes have previously been demonstrated to be the most frequent ...
Billingsley, G., Graw, Jochen, Heon, E., Illig, T., Klopp, N., Rudolph, G., Wjst, M.   +6 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Genome-Wide Identification and Expression Profiles of Myosin Genes in the Pacific White Shrimp, Litopenaeus vannamei

Frontiers in Physiology, 2019
As the main structural protein of muscle fiber, myosin is essential for multiple cellular processes or functions, especially for muscle composition and development.
Xiaoxi Zhang, Xiaoxi Zhang, Xiaoxi Zhang, Jianbo Yuan, Jianbo Yuan, Jianbo Yuan, Xiaojun Zhang, Xiaojun Zhang, Xiaojun Zhang, Chengzhang Liu, Chengzhang Liu, Chengzhang Liu, Fuhua Li, Fuhua Li, Fuhua Li, Jianhai Xiang, Jianhai Xiang, Jianhai Xiang   +17 more
doaj   +1 more source

Genome-wide identification and analysis of glyceraldehyde-3-phosphate dehydrogenase family reveals the role of GmGAPDH14 to improve salt tolerance in soybean (Glycine max L.)

Frontiers in Plant Science, 2023
IntroductionGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an essential key enzyme in the glycolytic pathway and plays an important role in stress responses.
Xunchao Zhao, Jie Wang, Ning Xia, Yuewen Qu, Yuhang Zhan, Weili Teng, Haiyan Li, Wenbin Li, Yongguang Li, Xue Zhao, Yingpeng Han   +10 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Genomic Fishing and Data Processing for Molecular Evolution Research

Methods and Protocols, 2022
Molecular evolution analyses, such as detection of adaptive/purifying selection or ancestral protein reconstruction, typically require three inputs for a target gene (or gene family) in a particular group of organisms: sequence alignment, model of ...
Héctor Lorente-Martínez, Ainhoa Agorreta, Diego San Mauro   +2 more
doaj   +1 more source

Genome-Wide Identification, Functional Analysis and Expression Profiling of the Aux/IAA Gene Family in Tomato [PDF]

, 2012
Auxin is a central hormone that exerts pleiotropic effects on plant growth including the development of roots, shoots, flowers and fruit. The perception and signaling of the plant hormone auxin rely on the cooperative action of several components,among
Abel, Abel, Abel, Bargmann, Carole Bassa, Chaabouni, Chaabouni, Corinne Audran-Delalande, Deng, Dharmasiri, Dharmasiri, Dreher, Eshed, Farid Regad, Finn, Hagen, Hamilton, Isabelle Mila, Jain, Jones, Kagale, Kalluri, Kepinski, Kloosterman, Leclercq, Li, Liscum, Mohamed Zouine, Mondher Bouzayen, Montgomery, Nebenführ, Oeller, Ohme-Takagi, Ottenschläger, Overvoorde, Paponov, Pirrello, Reed, Remington, Saitou, Sato, Szemenyei, Tamura, Tan, Theologis, Tiwari, Tiwari, Uehara, Ulmasov, Ulmasov, Wang, Wang, Wang, Wang, Yamamoto, Zuckerkandl   +55 more
core   +4 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source