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Intrinsic incompatibilities evolving as a by-product of divergent ecological selection : Considering them in empirical studies on divergence with gene flow [PDF]

open access: yesMolecular Ecology, 2017
The possibility of intrinsic barriers to gene flow is often neglected in empirical research on local adaptation and speciation with gene flow, for example when interpreting patterns observed in genome scans.
Kulmuni, J., Westram, A. M.
core   +2 more sources

Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas

open access: yesJournal for ImmunoTherapy of Cancer, 2021
Background Pediatric high-grade gliomas (pHGGs) are among the most common and incurable malignant neoplasms of childhood. Despite aggressive, multimodal treatment, the outcome of children with high-grade gliomas has not significantly improved over the ...
Malcolm K Brenner   +15 more
doaj   +1 more source

Population Transcriptomics Reveals Gene Flow and Introgression Between Two Non-sister Alpine Gentians

open access: yesFrontiers in Ecology and Evolution, 2021
Distributional shifts driven by Quaternary climatic oscillations have been suggested to cause interspecific hybridization and introgression. In this study, we aimed to test this hypothesis by using population transcriptomes and coalescent modeling of two
Chunlin Chen   +6 more
doaj   +1 more source

Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis

open access: yesFrontiers in Physiology, 2020
Chronic pancreatitis, a known risk factor for the development of pancreatic ductal adenocarcinoma (PDA), is a serious, widespread medical condition characterized by inflammation, fibrosis, and acinar to ductal metaplasia (ADM).
Kathleen E. DelGiorno   +9 more
doaj   +1 more source

Suppressing evolution in genetically engineered systems through repeated supplementation

open access: yesEvolutionary Applications, 2021
Genetically engineered organisms are prone to evolve in response to the engineering. This evolution is often undesirable and can negatively affect the purpose of the engineering.
Nathan C. Layman   +5 more
doaj   +1 more source

Variability and genetic structure in fragments of Eugenia involucrata De Candolle established through microsatellite markers [PDF]

open access: yesCiência Rural, 2021
ABSCTRACT: Eugenia involucrata DC. is a forest species with high environmental and economic potential. The objective of this study was to quantify the genetic variability and analyzed the genetic structure of three natural fragments located in the ...
Charlene Moro Stefanel   +4 more
doaj   +1 more source

Genetic diversity and population structure of the antimalarial plant Cryptolepis sanguinolenta in Ghana

open access: yesFrontiers in Conservation Science, 2022
Cryptolepis sanguinolenta is an important medicinal plant used in the treatment of malaria in Ghana. Overharvesting, destruction of entire plant populations and poor seed viability have resulted in a substantial decrease in wild populations thereby ...
Jacqueline Naalamle Amissah   +3 more
doaj   +1 more source

Reproductive Assurance Maintains Red-Flowered Plants of Lysimachia arvensis in Mediterranean Populations Despite Inbreeding Depression

open access: yesFrontiers in Plant Science, 2020
Flower color polymorphism, an infrequent but phylogenetically widespread condition in plants, is captivating because it can only be maintained under a few selective regimes but also because it can drive intra-morph assortative mating and promote ...
Francisco J. Jiménez-López   +3 more
doaj   +1 more source

The relevance of gene flow with wild relatives in understanding the domestication process [PDF]

open access: yesRoyal Society Open Science, 2020
The widespread use of genomic tools has allowed for a deeper understanding of the genetics and the evolutionary dynamics of domestication. Recent studies have suggested that multiple domestications and introgression are more common than previously ...
Alejandra Moreno-Letelier   +4 more
doaj   +1 more source

Fitness and Ecological Risk of Hybrid Progenies of Wild and Herbicide-Tolerant Soybeans With EPSPS Gene

open access: yesFrontiers in Plant Science, 2022
Exogenous genes of transgenic crops are usually transferred to their wild-type relatives through pollen-mediated gene flow, which may change the ecological fitness and ability to invade wild populations, resulting in the weeding of wild plants and other ...
Laipan Liu   +10 more
doaj   +1 more source

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