Results 161 to 170 of about 1,078,640 (312)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Dispersal Beyond Mountains and Borders: Asymmetrical Gene Flow Helps Maintain Brown Bear Metapopulation Connectivity on the Balkan Peninsula. [PDF]

Ecol Evol
Pylidis C, Matic I, Djan M, Valchev K, Ćirović D, Arangelov S, Walker S, Sarasua N, Mrazek V, Basuony AE, Bruford MW, Cuyten K, Hailer F.   +12 more
europepmc   +1 more source

The genetic structure of Beta vulgaris ssp. maritima (sea beet) populations: RFLPs and isozymes show different patterns of gene flow [PDF]

, 1996
Alan Raybould, R Mogg, Ralph T. Clarke
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Genomic Evidence for Dual Introductions, Limited Gene Flow and Niche Preferences in the Invasive Wasp Vespula germanica in South Africa. [PDF]

Mol Ecol
Gergonne D, Veldtman R, Bekker G, Hui C, van Asch B.   +4 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Speciation with gene flow in an island endemic hummingbird. [PDF]

PNAS Nexus
Judy CD, Graves GR, McCormack JE, Stryjewski KF, Brumfield RT.   +4 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Multi-centric origins and gene flow shape the diversity of β-thalassemia mutations in Southern East Asia. [PDF]

Nat Commun
Zhang Q, Li J, Huang H, Shang X, Ye Y, Zhang W, Lin P, Gong Y, Hoh BP, Luo Q, Yan T, Pan X, Stoneking M, Xu S, Xu X, Deng L.   +15 more
europepmc   +1 more source

Gene flow at a snail's pace: phylogeography and conservation genetics of relict populations of the Iowa Pleistocene snail

, 1998
Tamara Kay Ross
openalex   +1 more source