Results 201 to 210 of about 1,168,362 (261)

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Gene Flow and Habitat Heterogeneity Shape Coexistence Dynamics of Arctic Charr Morphs in Connected Lakes. [PDF]

Mol Ecol
Xiao H, Pálsson A, Jónsson ZO, Snorrason SS.   +3 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Genomic Evaluation of Assisted Gene Flow Options in an Endangered Rattlesnake. [PDF]

Mol Ecol
Mathur S, Gibbs HL.
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Accounting for gene flow from unsampled ghost populations while estimating evolutionary history. [PDF]

G3 (Bethesda)
Sethuraman A, Lynch M, Wanjiku M, Kuzminskiy M.   +3 more
europepmc   +1 more source

Speciation with gene flow in an island endemic hummingbird. [PDF]

PNAS Nexus
Judy CD, Graves GR, McCormack JE, Stryjewski KF, Brumfield RT.   +4 more
europepmc   +1 more source

Incorporating pollinator movement into connectivity models predicts pollen-mediated gene flow and highlights the importance of regenerating forests in tropical landscapes. [PDF]

Landsc Ecol
Davis KEC, Thomassen ES, Wagner HH, Kormann UG, Hadley AS, Betts MG, Torres-Vanegas F.   +6 more
europepmc   +1 more source

High Gene Flow With Patterns of Asymmetric Connectivity and Adaptive Divergence in the New Zealand Southern Rock Lobster, <i>Jasus edwardsii</i> (Hutton, 1875). [PDF]

Evol Appl
Mendiola MJR, Ilushkina I, Strugnell JM, Murphy N, Bell JJ, Gardner JPA.   +5 more
europepmc   +1 more source

Correction: Genomic regions of current low hybridisation mark long-term barriers to gene flow in scarce swallowtail butterflies. [PDF]

PLoS Genet
PLOS Genetics Staff.
europepmc   +1 more source