Results 51 to 60 of about 485,583 (269)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Identification of a recessive gene RgM4G52 conferring red glume, stem, and rachis in a Triticum boeoticum mutant

Frontiers in Plant Science
Anthocyanins are plant secondary metabolites belonging to the polyphenol class of natural water-soluble phytopigments. The accumulation of anthocyanins in different plant tissues can improve plant survival under adverse conditions.
Longyu Chen, Longyu Chen, Junqing Zhang, Junqing Zhang, Pan Ma, Pan Ma, Yongping Miao, Yongping Miao, Lei Wu, Lei Wu, Ke Zhou, Ke Zhou, Jiaru Yang, Jiaru Yang, Minghu Zhang, Xin Liu, Bo Jiang, Ming Hao, Lin Huang, Shunzong Ning, Xuejiao Chen, Xue Chen, Dengcai Liu, Dengcai Liu, Hongshen Wan, Hongshen Wan, Lianquan Zhang, Lianquan Zhang   +27 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Loss-of-Function of a Tomato Receptor-Like Kinase Impairs Male Fertility and Induces Parthenocarpic Fruit Set

Frontiers in Plant Science, 2019
Parthenocarpy arises when an ovary develops into fruit without pollination/fertilization. The mechanisms involved in genetic parthenocarpy have attracted attention because of their potential application in plant breeding and also for their elucidation of
Hitomi Takei, Hitomi Takei, Yoshihito Shinozaki, Yoshihito Shinozaki, Ryoichi Yano, Sachiko Kashojiya, Michel Hernould, Michel Hernould, Christian Chevalier, Hiroshi Ezura, Hiroshi Ezura, Tohru Ariizumi, Tohru Ariizumi   +12 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Fine mapping and characterization of Fusarium wilt (Fusarium oxysporum f. sp. benincasae) resistance gene Fob1(t) in wax gourd (Benincasa hispida Cogn.)

Frontiers in Plant Science
Fusarium wilt (FW), caused by the plant fungus Fusarium oxysporum, causes severe economic losses in wax gourd (Benincasa hispida Cogn.). Developing disease-resistant varieties is an effective measure.
Fahuo Li, Fahuo Li, Jian Qin, Jian Qin, Jingying Li, Jingying Li, Liang Cheng, Liang Cheng, Xuehan He, Xiaohui Zhong, Xiaohui Zhong, Yangpeng Mo, Yangpeng Mo, Han Liang, Han Liang, Peng Wang, Yan Li, Yan Li, Yongguan Wu, Yongguan Wu   +19 more
doaj   +1 more source

The Sorghum Gene for Leaf Color Changes upon Wounding (P) Encodes a Flavanone 4-Reductase in the 3-Deoxyanthocyanidin Biosynthesis Pathway

G3: Genes, Genomes, Genetics, 2016
Upon wounding or pathogen invasion, leaves of sorghum [Sorghum bicolor (L.) Moench] plants with the P gene turn purple, whereas leaves with the recessive allele turn brown or tan.
Hiroyuki Kawahigashi, Shigemitsu Kasuga, Yuji Sawada, Jun-ichi Yonemaru, Tsuyu Ando, Hiroyuki Kanamori, Jianzhong Wu, Hiroshi Mizuno, Mitsuru Momma, Zui Fujimoto, Masami Yokota Hirai, Takashi Matsumoto   +11 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Genetic Map Construction, QTL Mapping, and Candidate Genes Screening of Grain Size Traits in Common Buckwheat (Fagopyrum esculentum M.) [PDF]

, 2022
Xiaomei Fang, Yuanli Zhang, Jingbin Cui, Lingqing Yue, Jianbo Tao, Yigang Wang, Ruifeng Zhang, Jiaqi Liu, Aohua Jiang, Jian Zhang, Renwu Ruan, Zelin Yi   +11 more
openalex   +1 more source