Results 151 to 160 of about 308,702 (255)

DIAMOND2GO: rapid Gene Ontology assignment and enrichment detection for functional genomics. [PDF]

Front Bioinform
Golden C, Studholme DJ, Farrer RA.
europepmc   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Molecular Modeling and Gene Ontology Implicate SLC35F4 and SLC35F5 as Golgi-Associated Importers of Flavin-Adenine-Dinucleotide. [PDF]

Int J Mol Sci
Niu Z, Jiang D, Hardy DM.
europepmc   +1 more source

Epilepsy phenotype and gene ontology analysis of the 129 genes in a large neurodevelopmental disorders cohort. [PDF]

Front Neurol, 2023
Ko YJ, Kim SY, Lee S, Yoon JG, Kim MJ, Jun H, Kim H, Chae JH, Kim KJ, Kim K, Lim BC.   +10 more
europepmc   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Benchmarking multiple gene ontology enrichment tools reveals high biological significance, ranking, and stringency heterogeneity among datasets. [PDF]

Front Bioinform
de Oliveira FHS, Gomes FA, Feltes BC.
europepmc   +1 more source

Gene Ontology Analysis Highlights Biological Processes Influencing Responsiveness to Biological Therapy in Psoriasis. [PDF]

Pharmaceutics, 2023
Krušič M, Jezernik G, Potočnik U.
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Genetics of ovulatory dysfunction and infertility: a scoping review and gene ontology analysis. [PDF]

Front Endocrinol (Lausanne)
DiPietro EE, Sarasua SM, Hopkins CS, Ganakammal SR, Boccuto L, Hurwitz J.   +5 more
europepmc   +1 more source

DGH-GO: dissecting the genetic heterogeneity of complex diseases using gene ontology. [PDF]

BMC Bioinformatics, 2023
Asif M, Martiniano HFMC, Lamurias A, Kausar S, Couto FM.   +4 more
europepmc   +1 more source