Results 261 to 270 of about 426,507 (329)

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

Brain-Gene Ontology: Integrating Bioinformatics and Neuroinformatics Data, Information and Knowledge to Enable Discoveries

, 2006
Nikola Kasabov, Vishal Jain, Paulo Gottgtroy, Ľubica Beňušková, Frances Joseph   +4 more
openalex   +2 more sources

Genomic and Cis‐Regulatory Basis of a Plastic C3‐C4 Photosynthesis in Eleocharis Baldwinii

Advanced Science, EarlyView.
The sedge Eleocharis baldwinii remarkably switches between C3‐like and C4‐like photosynthesis in response to environmental conditions. Combining gap‐free genome assembly with single‐cell multi‐omics, this study uncovers how subgenome dominance and cell‐specific cis‐regulation enable C4 photosynthesis.
Lu Chen, Yanfeng Jia, Zaihui Zhou, Qiying Jiang, Jianlin Liu, Jianhui Gu, Chuan Chen, Shujing Cheng, Jinfang Chu, Xin Liu, Yongjun Lin, Xiang Li   +11 more
wiley   +1 more source

Gene ontology functional annotation datasets for the ITAG3.2 and ITAG4.0 tomato (Solanum lycopersicum) genome annotations. [PDF]

Data Brief
Rivera-Silva R, Chávez Montes RA, Jaimes-Miranda F.   +2 more
europepmc   +1 more source

Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived apoptotic bodies (MSC‐ABs) target keloid fibroblasts (KFs), restoring nicotinamide adenine dinucleotide (NAD) metabolism and mitochondrial function, suppressing collagen overproduction, and rebalancing tissue homeostasis, offering a novel therapy for keloid.
Shutong Qian, Siya Dai, Chunyi Guo, Wenjun Wang, Jiajia Pang, Yichen Shen, Mingyuan Xu, Jie Hu, Wenguo Cui, Xiaoming Sun, Jinghong Xu   +10 more
wiley   +1 more source

GOToolBox: functional analysis of gene datasets based on Gene Ontology.

, 2004
David Martin, Christine Brun, Élisabeth Rémy, Pierre Mouren, Bernard Jacq, Denis Thieffry   +5 more
openalex   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

p27 Cell Cycle Inhibitor and Survival in Luminal-Type Breast Cancer: Gene Ontology, Machine Learning, and Drug Screening Analysis. [PDF]

J Breast Cancer
Park IA, Noh YK, Min KW, Kim DH, Lee JY, Son BK, Kwon MJ, Han MH, Hur JY, Pyo JS.   +9 more
europepmc   +1 more source

Integrating Gene Expression Data from Microarrays Using the Self-Organising Map and the Gene Ontology

, 2007
Kenneth McGarry, Mohammad Sarfraz, John MacIntyre   +2 more
openalex   +1 more source

An Injectable BMP‐2‐Releasing Porous Hydrogel Regulating the Paracrine Effects of ADSCs Promotes Tendon‐to‐Bone Healing in Rotator Cuff Repair

Advanced Science, EarlyView.
This study designs an injectable porous hydrogel (HMs/MBs/ADSCs) integrating hollow microspheres for sustained BMP‐2 release to enhance adipose‐derived stem cells' paracrine effect. It accelerates tendon‐bone healing in rat rotator cuff injuries via spatiotemporal regulation: early AMPK‐mediated mitochondrial protection and late TGF‐β/Smad2/3‐driven ...
Meijuan Yuan, Xiaomei Dai, Yuxia Yang, Shuai Liu, Ziyi Xu, Liang Wang, Junli Shi, Wenkang Liu, Jian Yang, Dianwei Liu, Hang Yao, Wenyong Fei   +11 more
wiley   +1 more source