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Advanced Science, EarlyView.This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li +11 more
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Integrating Ontological Information about Genes
2014 IEEE 23rd International WETICE Conference, 2014With the advent of biological ontologies an increasing amount of methods are emerging for enriching gene information by means of their annotations. However, problems occur in assessing semantic similarity over genetic aspects that are represented independently in different schemas when, in reality, they are not.
DESSI, NICOLETTA +2 more
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Gene multifunctionality scoring using gene ontology
Journal of Bioinformatics and Computational Biology, 2018Multifunctional genes are important genes because of their essential roles in human cells. Studying and analyzing multifunctional genes can help understand disease mechanisms and drug discovery. We propose a computational method for scoring gene multifunctionality based on functional annotations of the target gene from the Gene Ontology. The method is
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Gene ontology analysis of arthrogryposis (multiple congenital contractures)
American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 2019In 2016, we published an article applying Gene Ontology Analysis to the genes that had been reported to be associated with arthrogryposis (multiple congenital contractures) (Hall & Kiefer, 2016).
J. Kiefer, J. Hall
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Methods for Gene Ontology Annotation
2007The Gene Ontology (GO) is an established dynamic and structured vocabulary that has been successfully used in gene and protein annotation. Designed by biologists to improve data integration, GO attempts to replace the multiple nomenclatures used by specialised and large biological knowledgebases.
Emily, Dimmer +3 more
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The ontology of the gene ontology.
AMIA ... Annual Symposium proceedings. AMIA Symposium, 2004The rapidly increasing wealth of genomic data has driven the development of tools to assist in the task of representing and processing information about genes, their products and their functions. One of the most important of these tools is the Gene Ontology (GO), which is being developed in tandem with work on a variety of bioinformatics databases.
Barry, Smith +2 more
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Gene function prediction with knowledge from gene ontology
International Journal of Data Mining and Bioinformatics, 2015Gene function prediction is an important problem in bioinformatics. Due to the inherent noise existing in the gene expression data, the attempt to improve the prediction accuracy resorting to new classification techniques is limited. With the emergence of Gene Ontology (GO), extra knowledge about the gene products can be extracted from GO and ...
Ying, Shen, Lin, Zhang
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Application of Gene Ontology to Gene Identification
2011Candidate gene identification deals with associating genes to underlying biological phenomena, such as diseases and specific disorders. It has been shown that classes of diseases with similar phenotypes are caused by functionally related genes. Currently, a fair amount of knowledge about the functional characterization can be found across several ...
Hugo P, Bastos +4 more
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