Results 111 to 120 of about 360,807 (164)
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Human Heredity, 1999
Hereditary hemochromatosis is an autosomal recessive disease characterized by progressive iron overload. Recently, a candidate gene named HFE was isolated on the short arm of the chromosome 6 within which two mutations were identified: C282Y and H63D.
V, Douabin +6 more
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Hereditary hemochromatosis is an autosomal recessive disease characterized by progressive iron overload. Recently, a candidate gene named HFE was isolated on the short arm of the chromosome 6 within which two mutations were identified: C282Y and H63D.
V, Douabin +6 more
openaire +2 more sources
Gene polymorphisms and transplantation
Current Opinion in Immunology, 2001The influence of gene polymorphisms in key immunoregulatory molecules on the clinical course post-transplant has become an area of active research, since it offers a possible explanation for the heterogeneity in outcomes between individuals. Several groups have now investigated the association of polymorphisms in molecules--including cytokines ...
E, Akalin, B, Murphy
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2013
Over the last decade, the explosive advances in sequencing and genotyping technologies fueled by major financial investments in basic science, have evidenced that hundreds of genes harboring variations contribute to human cancers and that genetic variability may influence patients' responses to post-surgical treatments (Hamburg and Collins, N Engl J ...
Siano, M, Vecchione, M, ILARDI, GENNARO
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Over the last decade, the explosive advances in sequencing and genotyping technologies fueled by major financial investments in basic science, have evidenced that hundreds of genes harboring variations contribute to human cancers and that genetic variability may influence patients' responses to post-surgical treatments (Hamburg and Collins, N Engl J ...
Siano, M, Vecchione, M, ILARDI, GENNARO
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Neutral drift and polymorphism in gene‐for‐gene systems
Ecology Letters, 2005AbstractPathogens are a main driving force of the evolution of plants and animals. Being resistant to diseases confers a high selective advantage to hosts, yet many host–pathogen systems show a remarkable degree of polymorphism of host resistance and pathogen virulence.
Salathe, Marcel +2 more
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Haplotypic polymorphisms of the TNFB gene
Immunogenetics, 1991The TNFB genes from two major histocompatibility complex (MHC) ancestral haplotypes have been compared. The genes carried by the ancestral haplotypes 8.1 (A1,B8,BfS,C4AQ0, C4B1,DR3) and 57.1 (A1, B57. BfS, C4A6, C4B1, DR7) were cloned and sequenced to determine the degree of polymorphism. In this report we show that the respective TNF genes are allelic
L J, Abraham +4 more
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Gene polymorphisms and behavior
Pediatric Blood & Cancer, 2007AbstractGenetics has a entered golden post genomic era that promises to greatly improve our understanding of the etiology of complex familial disorders. Many forms of behavior are familial but Mendelian disorders are rare, and common conditions have complex inheritance.
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Gene Polymorphisms in Female Reproduction
2014This chapter presents an overview of the gene polymorphisms underlying the functions of ovarian receptors and their clinical implications in the female fecundity. A selection of genetic studies revealing significant associations between receptor polymorphisms, gene mutations, and some pathological conditions (i.e., female infertility, premature ovarian
CASARINI, Livio, SIMONI, Manuela
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CYP2C19 gene polymorphism in Ningxia
Pharmacological Reports, 2023Poor metabolizer (PM) status of CYP2C19 can be a predisposing factor for developing gastric cancer in H. pylori-infected patients. It is unclear whether PM status of CYP2C19 can also be a potential factor for H.pylori infection in healthy people.We used high-throughput sequencing to detect single nucleotide polymorphisms (SNPs) at just three loci ...
Zhen Yang +8 more
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Gene polymorphisms in bladder cancer
Urologic Oncology: Seminars and Original Investigations, 2008In Europe, cancer of the bladder is the fourth most common cancer among men, accounting for 7% of total cancers. In the USA, bladder cancer is the fifth most common cancer in men and seventh in women. This disease is three times more common in men than in women.
Maria, Franekova +4 more
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