Results 51 to 60 of about 758,578 (355)

THE STRUCTURE OF THE GENETIC POLYMORPHISMS IN PATIENTS WITH METABOLIC SYNDROME AND A COMPLICATED PREGNANCY IN HISTORY

Акушерство, гинекология и репродукция, 2016
Objective. To analyze the structure of the gene polymorphisms of hemostasis, platelet receptors and enzymes of the folate cycle in patients with metabolic syndrome (MS) and a complicated pregnancy in history. Materials and Methods. The study included 115
A. V. Khromylev, A. D. Makatsariya
doaj   +1 more source

Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient [PDF]

, 2012
Peer reviewedPublisher ...
Andreatta, Matthew, Loudet, Olivier, Poormohammad Kiani, Seifollah, Robert, Thierry, Salt, David E, Simon, Matthieu, Trontin, Charlotte   +6 more
core   +6 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex. [PDF]

, 1989
Insertion/deletion related polymorphisms (IDRP) involving stretches of 15-30 kb within the human TCR-beta gene complex were revealed by pulse-field gel electrophoresis.
Hauser, SL, Kindt, TJ, Robinson, MA, Seboun, E   +3 more
core  

A four-month gatifloxacin-containing regimen for treating tuberculosis. [PDF]

, 2014
BACKGROUND: Shortening the course of treatment for tuberculosis would be a major improvement for case management and disease control. This phase 3 trial assessed the efficacy and safety of a 4-month gatifloxacin-containing regimen for treating rifampin ...
Amukoye, Evans, Bah, Boubacar, de Jong, Bouke C, Fielding, Katherine, Gninafon, Martin, Horton, John, Kassa, Ferdinand, Lapujade, Olivier, Lienhardt, Christian, Lo, Mame B, Merle, Corinne S, Mthiyane, Thuli, N'Diaye, Alimatou, Odhiambo, Joseph, OFLOTUB/Gatifloxacin for Tuberculosis Project, Olliaro, Piero L, Perronne, Christian, Rustomjee, Roxana, Sismanidis, Charalambos, Sow, Omou Bah   +19 more
core   +1 more source

A hidden cause of infertility in hypothyroid patients [PDF]

, 2020
Methylene tetrahydrofolate reductase (MTHFR) gene mutations could be the cause of infertility in hypothyroid patients. Hence, it is worthy to screen for MTHFR gene mutations in infertile hypothyroid females and their partners if infertility persists ...
Ahmed, Soha Magdy, Allam, Magdy Mohamed, Barakat, Sherine Samir, El-Zawawy, Hanaa Tarek, Saleh, Rasha Noureldin M.   +4 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development. [PDF]

PLoS ONE, 2015
The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer.Three ...
Feng-Yan Lin, Chiao-Wen Lin, Shun-Fa Yang, Wei-Jiunn Lee, Yung-Wei Lin, Liang-Ming Lee, Junn-Liang Chang, Wei-Chun Weng, Chien-Huang Lin, Ming-Hsien Chien   +9 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Evaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosis

Journal of Infection and Public Health, 2017
Objective: MBL acts as a binding protein that enables uptake of mycobacteria into macrophages. And, TNF-alpha is an important cytokine that is involved in control of mycobacterial infections both in-vivo and in-vitro.
Esma Ceylan, Mutlu Karkucak, Hikmet Coban, Mehmet Karadag, Tahsin Yakut   +4 more
doaj   +1 more source