Results 151 to 160 of about 3,252,139 (303)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

New insights in the Spanish gene pool of olive (Olea europaea L.) preserved ex situ and in situ based on high-throughput molecular markers. [PDF]

Front Plant Sci, 2023
Gómez-Gálvez FJ, Ninot A, Rodríguez JC, Compañ SP, Andreva JU, Rubio JAG, Aragón IP, Viñuales-Andreu J, Casanova-Gascón J, Šatović Z, Lorite IJ, De la Rosa-Navarro R, Belaj A.   +12 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Plastome-based phylogeny and biogeography of Lactuca L. (Asteraceae) support revised lettuce gene pool categories. [PDF]

Front Plant Sci, 2022
Chu R, Xu X, Lu Z, Ma Y, Cheng H, Zhu S, Bakker FT, Schranz ME, Wei Z.   +8 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Cross incompatibility restricting genome exchange and diversification of primary gene pool in plants: challenges and opportunities. [PDF]

Theor Appl Genet
Thudi M, Naik YD, Jha UC, Reddy MSS, Pandey MK, Mir RR, Aski MS, Jayakodi M, Mendu V, Puppala N, Prasad PVV, Punnuri SM, Nguyen HT.   +12 more
europepmc   +1 more source

Origins of East Caucasus Gene Pool: Contributions of Autochthonous Bronze Age Populations and Migrations from West Asia Estimated from Y-Chromosome Data. [PDF]

Genes (Basel), 2023
Agdzhoyan A, Iskandarov N, Ponomarev G, Pylev V, Koshel S, Salaev V, Pocheshkhova E, Kagazezheva Z, Balanovska E.   +8 more
europepmc   +1 more source

[Texas Historical Commission Marker: Pool Manufacturing Company]

, 2011
Photograph of the Texas Historical Commission marker for Pool Manufacturing Company in Sherman, Texas. Text: BACK Originally chartered September 20, 1909, as Sherman Overall Manufacturing.
West, Carolyn Effie
core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Exploring the gene pool of Brassica napus by genomics-based approaches. [PDF]

Plant Biotechnol J, 2021
Hu D, Jing J, Snowdon RJ, Mason AS, Shen J, Meng J, Zou J.   +6 more
europepmc   +1 more source