KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Intramolecular integration within Moloney murine leukemia virus DNA [PDF]
, 1981 By screening a library of unintegrated, circular Moloney murine leukemia virus (M-MuLV) DNA cloned in lambda phage, we found that approximately 20% of the M-MuLV DNA inserts contained internal sequence deletions or inversions.
Baltimore, David +3 more
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Quantitative Analysis of Transcript Accumulation from Genes Duplicated by Polyploidy Using cDNASSCP
BioTechniques, 2003 Repeated rounds of polyploidy have been commonplace in the lineages leading to modern eukaryotic genomes, giving rise to widespread gene duplication. Genes duplicated by polyploidy, or “homoeologs,” may continue to be expressed at equal levels following ...
Richard C. Cronn, Keith L. Adams
doaj +1 more source
Correlated substitutions reveal SARS-like coronaviruses recombine frequently with a diverse set of structured gene pools. [PDF]
Proc Natl Acad Sci U S A, 2023 Preska Steinberg A +2 more
europepmc +1 more source
Robust identification of local adaptation from allele frequencies
, 2012 Comparing allele frequencies among populations that differ in environment has long been a tool for detecting loci involved in local adaptation. However, such analyses are complicated by an imperfect knowledge of population allele frequencies and neutral ...
Graham Coop +8 more
core +1 more source
Leveraging multiple sequencing technologies to generate a haplotype specific assembly of sugarcane R570. [W1018] [PDF]
, 2020 While sugarcane is one of the world's most important economic grasses for its sugar production and biofuel potential, tools and resources to understand its genetics are lacking.
Aitken, Karen S. +8 more
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Prevalence of Deltaproteobacterial sequences in nifH gene pools associated with the rhizosphere of native switchgrass from Tall Grass Prairie (Oklahoma, USA). [PDF]
3 Biotech, 2023 Bahulikar RA.
europepmc +1 more source
Comparison of reproducibility, accuracy, sensitivity, and specificity of miRNA quantification platforms [PDF]
, 2019 Given the increasing interest in their use as disease biomarkers, the establishment of reproducible, accurate, sensitive, and specific platforms for microRNA (miRNA) quantification in biofluids is of high priority.
Barczak, Andrea J +8 more
core +1 more source