Results 61 to 70 of about 2,702,537 (246)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Identification of Stem Rust Resistance Genes in Triticum Wheat Cultivars and Evaluation of Their Resistance to Puccinia graminis f. sp. tritici

Agriculture
Wheat stem rust, caused by the fungus Puccinia graminis f. sp. tritici (Pgt), poses a substantial threat to global wheat production. Utilizing stem rust resistance (Sr) genes represents an economically viable, effective, and environmentally friendly ...
Fu Gao, Xianxin Wu, Huiyan Sun, Ziye Wang, Si Chen, Longmei Zou, Jinjing Yang, Yifan Wei, Xinyu Ni, Qian Sun, Tianya Li   +10 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The Cytomegalovirus Protein Kinase pUL97: Host Interactions, Regulatory Mechanisms and Antiviral Drug Targeting

Microorganisms, 2020
Human cytomegalovirus (HCMV) expresses a variety of viral regulatory proteins that undergo close interaction with host factors including viral-cellular multiprotein complexes.
Mirjam Steingruber, Manfred Marschall
doaj   +1 more source

Polarized Interpolation and Normal Postulation for Curves on Fano Hypersurfaces [PDF]

A general hypersurface X of degree at most n in projective (n + 1)-space contains curves C of any genus g ≥ 0 and sufficiently large degree depending on g whose normal and conormal bundles in X have good postulation or natural cohomology in a sense that ...
Ran, Ziv
core   +1 more source

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Multiple patho-phenotyping and molecular analysis to characterize wide-spectrum durable leaf rust resistance in wheat collections from India

Frontiers in Microbiology
Wheat leaf rust, caused by Puccinia triticina (Pt), is a globally prevalent fungal disease that causes significant economic loss. Cultivar resistance remains a cornerstone of the management of this pathogen. This study evaluated 86 Indian wheat (Triticum
Ram Mohan, Vaibhav Kumar Singh, K. K. Chetan, Lingareddy Usha Rani, Koshal K. Sameriya, Subodh Kumar, Naresh Kumar Bainsla, Govindasamy Senthilraja, Mahender Singh Saharan   +8 more
doaj   +1 more source

miR-26a-5p is a Stable Reference Gene for miRNA Studies in Chondrocytes from Developing Human Cartilage

Cells, 2019
miRNAs are emerging as key regulators of complex biological systems in several developmental processes. qRT-PCR is a powerful tool to quantitatively assess the profiles and modulation of miRNA expression.
Enrico Ragni, Paola De Luca, Antongiulio Marmotti, Laura de Girolamo   +3 more
doaj   +1 more source

Postulation and mapping of seedling stripe rust resistance genes in Ethiopian bread wheat cultivars

, 2012
Stripe rust caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most important diseases of wheat worldwide. In Ethiopia, grain yield loss in wheat cultivars ranges from 30 to 69%.
Weber, W. E., Schumann, E., Dawit, Waubit, Röder, M. S., Chen, X., Flath, Kerstin   +5 more
core   +1 more source