Results 211 to 220 of about 9,720,197 (382)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Integrated de novo gene prediction and peptide assembly of metagenomic sequencing data. [PDF]

open access: yesNAR Genom Bioinform, 2023
Thippabhotla S   +6 more
europepmc   +1 more source

Gene modeling and prediction v1

open access: yes, 2018
We performed a considerate prediction of intact protein-coding gene models using three independent approaches, i.e.,de novoprediction, homology-based method, and RNA-Seq approach.
openaire   +2 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

FAM family gene prediction model reveals heterogeneity, stemness and immune microenvironment of UCEC. [PDF]

open access: yesFront Mol Biosci, 2023
Chi H   +14 more
europepmc   +1 more source

GeneMachine: gene prediction and sequence annotation [PDF]

open access: bronze, 2001
Izabela Makałowska   +2 more
openalex   +1 more source

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