Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Clinical significance and gene prediction of a novel classification system based on tacrolimus concentration-to-dose ratio in the early post-liver transplant period. [PDF]
Fan J +6 more
europepmc +1 more source
MOSES: A New Approach to Integrate Interactome Topology and Functional Features for Disease Gene Prediction. [PDF]
Petti M +6 more
europepmc +1 more source
Prediction of human protein function according to Gene Ontology categories [PDF]
Lars Juhl Jensen +3 more
openalex +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Enhancing Molecular Network-Based Cancer Driver Gene Prediction Using Machine Learning Approaches: Current Challenges and Opportunities. [PDF]
Zhang H +6 more
europepmc +1 more source
ResCap: plant resistance gene prediction and probe generation pipeline for resistance gene sequence capture. [PDF]
Kushwaha SK, Åhman I, Bengtsson T.
europepmc +1 more source
The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia [PDF]
Hiroyasu Ogawa +15 more
openalex +1 more source

